{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T19:04:52Z","timestamp":1772737492159,"version":"3.50.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; Atrial fibrillation (AF) is rare during childhood and usually associated with other cardiovascular pathology. In lone AF, the ventricular response rate is usually rapid. We sought to describe a subset of children who present with early-onset AF and a slow ventricular response rate who were found to have the short QT syndrome (SQTS). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Using a MEDLINE\/PubMed search, children with AF, a structurally normal heart and bradycardia were identified. Demographics, clinical presentation, electrocardiographic (ECG) findings, electrophysiologic testing, genetic analysis and follow-up assessment were collected on each child for analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Four children were identified in the literature and combined with 2 other children followed by the authors. All had a short QT interval and those who were tested were found to have a gain-of-function mutation in the KCNQ1 gene. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; We describe a subclass of children with SQTS who present with AF and a slow ventricular response. Medical therapy has not been effective in maintaining sinus rhythm. The long-term outcome remains unknown for these children. This condition may present in utero as persistent bradycardia with postnatal ECG showing a very short QT interval.<\/jats:p>","DOI":"10.1159\/000360758","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:47:45Z","timestamp":1492552065000},"page":"236-240","source":"Crossref","is-referenced-by-count":28,"title":["Short QT Syndrome Manifesting with Neonatal Atrial Fibrillation and Bradycardia"],"prefix":"10.1159","volume":"128","author":[{"given":"Juan","family":"Villafa\u00f1e","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Fischbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Gebauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cjca.2013.06.014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hrthm.2010.09.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hrthm.2008.02.007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hrthm.2013.07.012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hrthm.2013.07.023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehl185"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.1218154110"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250600763042"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cardiores.2005.06.023"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5273%2891%2990014-G"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.44.6.684"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000178470"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000130409.72142.FE"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2012.12.025"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000047299"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360758","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:32:41Z","timestamp":1745429561000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000360758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,6,1]]},"published-print":{"date-parts":[[2014,6,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000360758","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}