{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:56:13Z","timestamp":1792515373637,"version":"4.5.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Background: Trigeminal neuralgia (TN) related to multiple sclerosis (MS) is more difficult to manage pharmacologically and surgically. Objective: This article aims to evaluate the safety and efficacy of Gamma Knife surgery (GKS) in this special group of patients. Methods: Between July 1992 and November 2010, 43 cases with more than 1 year of follow-up were operated with GKS for TN related to MS and prospectively evaluated in the Timone University Hospital, Marseille, France. Radiosurgery using the Gamma Knife (model B or C or Perfexion) was performed. A single 4-mm isocenter was positioned at a median distance of 8 mm (range 5.7-14.7) anterior to the emergence of the nerve. A median maximum dose of 85 Gy (range 75-90) was delivered. Results: The median follow-up period was 53.8 months (12-157.1). Thirty-nine patients (90.7%) were initially pain free. Their actuarial probability of remaining pain free without medication at 6 months, 1, 3, 5 and 10 years was 87.2, 71.8, 43.1, 38.3 and 20.5%, respectively, and remained stable till 12 years. The hypoesthesia actuarial rate at 6 months, 1 and 2 years was 11.5, 11.5 and 16%, and remained stable till 12 years. Conclusions: GKS proved safe and effective in this special group of patients.<\/jats:p>","DOI":"10.1159\/000362173","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T07:01:51Z","timestamp":1404802911000},"page":"203-210","source":"Crossref","is-referenced-by-count":54,"title":["Multiple Sclerosis-Related Trigeminal Neuralgia: A Prospective Series of 43 Patients Treated with Gamma Knife Surgery with More than One Year of Follow-Up"],"prefix":"10.1159","volume":"92","author":[{"given":"Constantin","family":"Tuleasca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Carron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Resseguier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Donnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gaudart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Levivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-3753","authenticated-orcid":false,"given":"Jean","family":"R\u00e9gis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.12.1830"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200001000-00028"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000137656.59536.0E"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s007010070113"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.630"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000069503"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000354815"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bacfb4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2003.00824.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2005.18.5.4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.6.913"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00513-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.0305-1846.2001.00318.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1982.tb03076.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.12.2347"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199408000-00017"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.1.59"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.3.253"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.1.0183"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.7.1294"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1987.00520160021008"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3109\/02688697.2011.591849"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000056423"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02185.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)94422-7"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000075105"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/sfn\/article-pdf\/92\/4\/203\/3905338\/000362173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/sfn\/article-pdf\/92\/4\/203\/3905338\/000362173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:36:39Z","timestamp":1745429799000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000362173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,9,1]]},"published-print":{"date-parts":[[2014,9,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000362173","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}