{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:18:11Z","timestamp":1760955491101,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background: &lt;\/i&gt;&lt;\/b&gt;The combination of radiotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib in patients with advanced or metastatic non-small cell lung cancer (NSCLC) has not been widely investigated. For afatinib, a new second generation irreversible pan-EGFR TKI, no clinical trials in this setting have as yet been performed. &lt;b&gt;&lt;i&gt;Case Report: &lt;\/i&gt;&lt;\/b&gt;We report a patient with a pretreated metastatic NSCLC receiving afatinib in combination with concomitant palliative radiotherapy to the mediastinum and primary lung tumor. The treatment was feasible and well tolerated. The patient achieved a partial response in the irradiated tumor region and the metastatic sites. &lt;b&gt;&lt;i&gt;Conclusion: &lt;\/i&gt;&lt;\/b&gt;The combination of afatinib and radiotherapy is promising and should be investigated further. However, because of the limited experience and potential side effects known for other EGFR TKIs, a decision for treatment outside a clinical trial has to be made very carefully, balancing the risk and benefit on an individual patient basis.<\/jats:p>","DOI":"10.1159\/000362488","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T06:43:42Z","timestamp":1398235422000},"page":"262-265","source":"Crossref","is-referenced-by-count":4,"title":["Afatinib with Concurrent Radiotherapy in a Patient with Metastatic Non-Small Cell Lung Cancer"],"prefix":"10.1159","volume":"37","author":[{"given":"Akin","family":"Atmaca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah-Eddin","family":"Al-Batran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Allg\u00e4uer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,4,14]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1056\/NEJMoa0810699"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016\/S1470-2045(11)70393-X"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016\/j.ijrobp.2010.12.035"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1097\/JTO.0b013e3181c59a0e"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1097\/JTO.0b013e31818396a4"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016\/j.lungcan.2010.12.007"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1093\/annonc\/mds012"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016\/j.lungcan.2010.08.016"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016\/j.ijrobp.2010.01.048"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1097\/JTO.0b013e3181653cf4"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1097\/JTO.0b013e3181eba657"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016\/j.lungcan.2007.07.015"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1159\/000337616"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.3816\/CLC.2008.n.044"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1200\/JCO.2012.44.2806"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016\/S1470-2045(12)70087-6"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1016\/j.lungcan.2011.04.017"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1016\/j.ejca.2012.10.020"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:39:35Z","timestamp":1745429975000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000362488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000362488","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2014]]}}}