{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:24Z","timestamp":1745469084825,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> The increase in the use of monoclonal antibodies (mAB) as a targeted therapy for a variety of diseases has been accompanied by an increase in reports of interstitial lung abnormalities in treated patients. <b><i>Objective:<\/i><\/b> Bronchoalveolar lavage (BAL) is routinely performed in these patients to rule out infection, so we sought to determine the BAL cellular pattern in individuals with mAB-induced lung disease (mAB-ILD). <b><i>Methods:<\/i><\/b> We utilized a case-control study design. Among patients treated with mAB, cases were defined as those with otherwise-unexplained interstitial lung abnormalities, which resolved after cessation of treatment, while controls were defined as those with interstitial abnormalities clearly explained by other etiologies. <b><i>Results:<\/i><\/b> From 2000 to 2012, we identified 9 cases and 7 controls. The mean age of the cases was 62.6 \u00b1 26 years and 6 were female. The most common radiographic finding was diffuse ground-glass opacities. The most common BAL cellular pattern was mixed inflammation with moderate lymphocytic and mild neutrophilic alveolitis. The cases had a higher mean lymphocyte count than the controls (40.1 \u00b1 32.6 vs. 13.1 \u00b1 25.5, p = 0.008). The rest of the BAL cellular analyses were similar between the 2 groups. The median CD4:CD8 ratio in 7 patients with >15% lymphocytes was 0.9 (0.6-3). There was no significant difference in the CD4:CD8 ratio between the 2 groups. <b><i>Conclusions:<\/i><\/b> Mixed inflammation with moderate lymphocytic and mild neutrophilic alveolitis is the most common BAL cellular pattern in patients with mAB-ILD. Such findings may be useful for the early identification of mAB-ILD.<\/jats:p>","DOI":"10.1159\/000362521","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T07:01:38Z","timestamp":1410418898000},"page":"185-189","source":"Crossref","is-referenced-by-count":3,"title":["Bronchoalveolar Lavage Cellular Patterns in Monoclonal Antibody-Induced Lung Disease"],"prefix":"10.1159","volume":"88","author":[{"given":"Shikha","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homer L.","family":"Twigg III","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chadi A.","family":"Hage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.11.028"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu236cr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200306263482619"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0320ST"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(03)00143-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20101"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.11.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080209"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31823ee5bf"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31824c07e8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker290"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.3298"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-03-2012-5973"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-137OC"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.68.9.782"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.99.179"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1734"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.08.001"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:39:51Z","timestamp":1745429991000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000362521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,9,1]]},"published-print":{"date-parts":[[2014,9,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000362521","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2014]]}}}