{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:26:47Z","timestamp":1793888807347,"version":"4.8.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Objectives:<\/i><\/b> Mutation of the exon 3 of <i>CTNNB1<\/i>, the coding gene of \u03b2-catenin, is a crucial molecular mechanism leading to aberrant activation of the Wnt\/\u03b2-catenin pathway, which is highly associated with the carcinogenesis of hepatocellular carcinoma (HCC). The prevalence and clinical significance of <i>CTNNB1<\/i> mutations in advanced HCC remain unclear. <b><i>Methods:<\/i><\/b> Patients with advanced HCC and available pathologic tissues (either obtained when diagnosed at advanced or early stages) were enrolled in this study. Direct sequencing of exon 3 of <i>CTNNB1<\/i> was performed to detect somatic mutations. The associations between <i>CTNNB1<\/i> mutations and clinicopathologic features were analyzed. <b><i>Results:<\/i><\/b> A total of 115 patients were enrolled, among whom 78 (67.8%) had chronic hepatitis B virus infection. Twenty-one (18.3%) patients were found to have <i>CTNNB1<\/i> mutations, all of which were missense mutations. The <i>CTNNB1<\/i> mutation rates were similar among pathologic tissues obtained at advanced and early stages (17.5 and 20.0%, respectively). Patients aged over 60 years were more likely to have <i>CTNNB1<\/i> mutations than patients younger than 60 years (32.6 vs. 8.7%, p = 0.001). The mutations were not associated with survival or other clinicopathologic features. <b><i>Conclusion:<\/i><\/b> In patients with advanced HCC, <i>CTNNB1<\/i> mutations were not prognostically significant. No apparent increase of <i>CTNNB1<\/i> mutations occurred during the progression of HCC.<\/jats:p>","DOI":"10.1159\/000362821","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T07:01:51Z","timestamp":1404802911000},"page":"159-166","source":"Crossref","is-referenced-by-count":45,"title":["\u03b2-Catenin<b><i> (CTNNB1)<\/i><\/b> Mutations Are Not Associated with Prognosis in Advanced Hepatocellular Carcinoma"],"prefix":"10.1159","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-9491","authenticated-orcid":false,"given":"Li-Chun","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-1912","authenticated-orcid":false,"given":"Yu-Yun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsuan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Shu","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Huang","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Fong","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chu","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Lii","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hung","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094291"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.10.018"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2389"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8847"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.4.5.647"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02430.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64590-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010701)92:1<136::AID-CNCR1301>3.0.CO;2-R"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(00)00116-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05250.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ng.903"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2291"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2256"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2943"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2039"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1373-x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2322"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1089"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0742"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362821","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:42:58Z","timestamp":1745430178000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000362821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,7,1]]},"published-print":{"date-parts":[[2014,7,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000362821","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}