{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:45:12Z","timestamp":1759340712664,"version":"3.40.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The use of 1\u03b1-hydroxylated vitamin D therapy to control secondary hyperparathyroidism in renal failure patients has been a success story, culminating with the demonstration of increased life expectancy in patients treated with these compounds. However, hypercalcemic episodes have been a recurrent problem with these therapies and have resulted in the added use of calcium mimetics. Clearly there is good reason to search for improved vitamin D therapy. In our inventory of vitamin D compounds, 2-methylene-19-nor-(20S)-1\u03b1,25-dihydroxyvitamin D&lt;sub&gt;3&lt;\/sub&gt; (2MD) surfaced as a potential candidate. This was based on its preferential localization in the parathyroid gland and a clear suppression of serum parathyroid hormone (PTH) levels without a change in serum calcium in a clinical trial in postmenopausal women. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 2MD has now been tested in the rat 5\/6-nephrectomy model of renal failure, and in postmenopausal women to determine if it can suppress serum PTH at doses that do not elevate serum calcium and serum phosphorus concentrations. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Daily oral treatment of uremic rats on 2.5 ng\/bw\/day of 2MD dramatically suppressed PTH without a change in serum calcium or serum phosphorus. Further, PTH was suppressed in postmenopausal women after only 3 daily oral doses of 2MD that continued for 4 weeks with no change in serum calcium or serum phosphorus. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; These results coupled with a pharmacokinetic half-life of ~24 h suggest that 2MD given either daily or at the time of dialysis may be a superior therapy for secondary hyperparathyroidism in chronic renal failure patients.<\/jats:p>","DOI":"10.1159\/000362846","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T08:19:26Z","timestamp":1402474766000},"page":"476-483","source":"Crossref","is-referenced-by-count":14,"title":["Novel, Selective Vitamin D Analog Suppresses Parathyroid Hormone in Uremic Animals and Postmenopausal Women"],"prefix":"10.1159","volume":"39","author":[{"given":"Julia B.","family":"Zella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori A.","family":"Plum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Plowchalk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Potochoiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Clagett-Dame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector F.","family":"DeLuca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2871%2990332-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1021%2Fbi00850a001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.1970.00310110166030"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1976.125"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1021%2Fbi00790a023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2F228764a0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.172.3989.1232"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-90-3-605"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.176.4039.1146"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI108424"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9861%2876%2990222-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.89.17.8097"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000085687"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI111639"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2877%2981261-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfi186"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0272-6386%2895%2990455-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fjbmr.5650070215"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa022536"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.202471299"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fjbmr.256"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1006%2Fabio.1997.2439"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2010-1109"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1021%2Fbi960658i"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1021%2Fbi9923757"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI107214"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa031633"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa1205624"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1021%2Fjm9802618"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1021%2Fbi101488p"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114229"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362846","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/362846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:43:15Z","timestamp":1745430195000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000362846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,7,1]]},"published-print":{"date-parts":[[2014,7,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000362846","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"type":"print","value":"0250-8095"},{"type":"electronic","value":"1421-9670"}],"subject":[],"published":{"date-parts":[[2014]]}}}