{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:59:53Z","timestamp":1791298793998,"version":"4.1.0"},"reference-count":25,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":4190,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The incidence of differentiated thyroid carcinoma (DTC) is low in people of African origin and higher in populations living on islands, but there is no well-established explanation for these differences. Cuba is a multiethnic nation with people of African and Spanish descent. Until now, no study on the risk factors of DTC has focused on the Cuban population. Our aim is to establish the role of environmental and lifestyle factors and to relate anthropometric measurements to the risk of developing DTC in Cuba. Methods: We performed a case-control study of 203 DTC patients treated in two hospitals in Havana and 212 controls living in the area covered by these hospitals (i.e. parts of Havana and the municipality of Jaruco). Risk factors were analyzed using conditional logistic regression. Results: As has been shown by other studies, we found that non-African ethnicity, never smoking, parity, and high body mass index are risk factors significantly associated with DTC, whereas a history of exposure to ionizing radiation and level of education were not significantly related with disease development. Being rhesus factor-positive, having a personal history of benign thyroid disorder, agricultural occupation, and consumption of artesian well water were also associated with a significantly increased risk of developing DTC. Conclusions: The original findings reported here concern the risk of DTC that was associated with non-African ethnicity, positive rhesus factor, farming, and drinking water from an artesian well.<\/jats:p>","DOI":"10.1159\/000362928","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T02:24:56Z","timestamp":1409192696000},"page":"189-196","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":10,"title":["Environmental, Lifestyle, and Anthropometric Risk Factors for Differentiated Thyroid Cancer in Cuba: A Case-Control Study"],"prefix":"10.1530","volume":"3","author":[{"given":"Juan J.","family":"Lence-Anta","sequence":"first","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Xhaard","sequence":"additional","affiliation":[{"name":"4Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba"},{"name":"5Institut Gustave Roussy, Havana, Cuba"},{"name":"6University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoiinda","family":"Kassim","sequence":"additional","affiliation":[{"name":"4Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba"},{"name":"5Institut Gustave Roussy, Havana, Cuba"},{"name":"6University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia M.","family":"Pereda","sequence":"additional","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Turcios","sequence":"additional","affiliation":[{"name":"2National Institute of Endocrinology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Velasco","sequence":"additional","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mae","family":"Chappe","sequence":"additional","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idalmis","family":"Infante","sequence":"additional","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Bustillo","sequence":"additional","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabel","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enora","family":"Clero","sequence":"additional","affiliation":[{"name":"4Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba"},{"name":"5Institut Gustave Roussy, Havana, Cuba"},{"name":"6University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Maillard","sequence":"additional","affiliation":[{"name":"4Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba"},{"name":"5Institut Gustave Roussy, Havana, Cuba"},{"name":"6University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirced","family":"Salazar","sequence":"additional","affiliation":[{"name":"1Institute of Oncology and Radiobiology, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regla","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"3Cuban Health Public Ministry, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"de Vathaire","sequence":"additional","affiliation":[{"name":"4Radiation Epidemiology Group, 1018 INSERM Unit, Havana, Cuba"},{"name":"5Institut Gustave Roussy, Havana, Cuba"},{"name":"6University Paris-Sud, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"2026070712444777100_ref1","doi-asserted-by":"crossref","unstructured":"Leenhardt L, Bernier MO, Boin-Pineau MH, et al: Advances in diagnostic practices affect thyroid cancer incidence in France. Eur J Endocrinol 2004;150:133-139.10.1530\/eje.0.150013314763910","DOI":"10.1530\/eje.0.1500133"},{"key":"2026070712444777100_ref2","doi-asserted-by":"crossref","unstructured":"Kilfoy BA, Zheng T, Holford TR, et al: International patterns and trends in thyroid cancer incidence, 1973-2002. Cancer Causes Control 2009;20:525-531.10.1007\/s10552-008-9260-419016336","DOI":"10.1007\/s10552-008-9260-4"},{"key":"2026070712444777100_ref3","doi-asserted-by":"crossref","unstructured":"Dieye M, Veronique-Baudina J, Draganescu C, Azaloux H: Cancer incidence in Martinique: a model of epidemiological transition. Eur J Cancer Prev 2007;16:95-101.10.1097\/01.cej.0000236246.78736.5117297384","DOI":"10.1097\/01.cej.0000236246.78736.51"},{"key":"2026070712444777100_ref4","doi-asserted-by":"crossref","unstructured":"Colonna M, Bossard N, Guizard AV, Remontet L, Grosclaude P: Descriptive epidemiology of thyroid cancer in France: incidence, mortality and survival. Ann Endocrinol 2010;71:95-101.10.1016\/j.ando.2009.11.00620036351","DOI":"10.1016\/j.ando.2009.11.006"},{"key":"2026070712444777100_ref5","doi-asserted-by":"crossref","unstructured":"Yu GP, Li JC, Branovan D, McCormick S, Schantz SP: Thyroid cancer incidence and survival in the National Cancer Institute surveillance, epidemiology, and end results race\/ethnicity groups. Thyroid 2010;20:465-473.10.1089\/thy.2008.028120384488","DOI":"10.1089\/thy.2008.0281"},{"key":"2026070712444777100_ref6","unstructured":"Henderson BE, Kolonel LN, Dworsky R, et al: Cancer incidence in the islands of the Pacific. Natl Cancer Inst Monogr 1985;69:73-81.3834349"},{"key":"2026070712444777100_ref7","unstructured":"Moore MA, Baumann F, Foliaki S, et al: Cancer epidemiology in the Pacific Islands - past, present and future. Asian Pac J Cancer Prev 2010;11:99-106.20553071"},{"key":"2026070712444777100_ref8","doi-asserted-by":"crossref","unstructured":"Pellegriti G, De Vathaire F, Scollo C, et al: Papillary thyroid cancer incidence in the volcanic area of Sicily. J Natl Cancer Inst 2009;101:1575-1583.10.1093\/jnci\/djp35419893009","DOI":"10.1093\/jnci\/djp354"},{"key":"2026070712444777100_ref9","doi-asserted-by":"crossref","unstructured":"Kristbjornsdottir A, Rafnsson V: Incidence of cancer among residents of high temperature geothermal areas in Iceland: a census-based study 1981-2010. Environ Health 2012;11:73.10.1186\/1476-069X-11-7323025471","DOI":"10.1186\/1476-069X-11-73"},{"key":"2026070712444777100_ref10","doi-asserted-by":"crossref","unstructured":"Clero E, Leux C, Brindel P, et al: Pooled analysis of two case-control studies in New Caledonia and French Polynesia of body mass index and differentiated thyroid cancer: the importance of body surface area. Thyroid 2010;20:1285-1293.10.1089\/thy.2009.045620932181","DOI":"10.1089\/thy.2009.0456"},{"key":"2026070712444777100_ref11","doi-asserted-by":"crossref","unstructured":"Peterson E, De P, Nuttall R: BMI, diet and female reproductive factors as risks for thyroid cancer: a systematic review. PLoS One 2012;7:e29177.10.1371\/journal.pone.002917722276106","DOI":"10.1371\/journal.pone.0029177"},{"key":"2026070712444777100_ref12","doi-asserted-by":"crossref","unstructured":"Dal Maso L, Bosetti C, La Vechia C, Franceschi S: Risk factors for thyroid cancer: an epidemiological review focused on nutritional factors. Cancer Causes Control 2009;20:75-86.10.1007\/s10552-008-9219-518766448","DOI":"10.1007\/s10552-008-9219-5"},{"key":"2026070712444777100_ref13","unstructured":"Cuban National Bureau of Statistics, Havana, Cuba 2012. http:\/\/www.one.cu\/Estadistica Poblacion\/EstadisticaPoblacion.asp."},{"key":"2026070712444777100_ref14","unstructured":"Dacal R, Rivero de la Calle M: Art and Archaeology of Pre-Columbian Cuba. Pittsburgh, University of Pittsburgh Press, 1996."},{"key":"2026070712444777100_ref15","unstructured":"MINSAP-DNE: Anuario estad\u00edstico de salud (Annual Report of Health Statistics) 2012. Havana, Direcci\u00f3n Nacional de Registros M\u00e9dicos y Estad\u00edsticas de Salud, 2013."},{"key":"2026070712444777100_ref16","unstructured":"Boyd E: The Growth of the Surface of the Human Body. Minneapolis, University of Minnesota Press, 1935."},{"key":"2026070712444777100_ref17","doi-asserted-by":"crossref","unstructured":"Polotsky HN, Brokhin M, Omry G, Polotsky AJ, Tuttle RM: Iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related increases in body mass in thyroid cancer survivors. Clin Endocrinol (Oxf) 2012;76:582-585.10.1111\/j.1365-2265.2011.04264.x22004309","DOI":"10.1111\/j.1365-2265.2011.04264.x"},{"key":"2026070712444777100_ref18","unstructured":"Hershman JM: Smoking may decrease the incidence of thyroid cancer in postmenopausal women. Clin Thyroidol 2012;24:8-9.10.1016\/j.canep.2012.03.013"},{"key":"2026070712444777100_ref19","doi-asserted-by":"crossref","unstructured":"Kabat GC, Kim MY, Wactawski-Wende J, Rohan TE: Smoking and alcohol consumption in relation to risk of thyroid cancer in postmenopausal women. Cancer Epidemiol 2012;36:335-340.10.1016\/j.canep.2012.03.01322525339","DOI":"10.1016\/j.canep.2012.03.013"},{"key":"2026070712444777100_ref20","doi-asserted-by":"crossref","unstructured":"Kitahara CM, Linet MS, Beane LE, et al: Cigarette smoking, alcohol intake, and thyroid cancer risk: a pooled analysis of five prospective studies in the United States. Cancer Causes Control 2012;23:1615-1624.10.1007\/s10552-012-0039-222843022","DOI":"10.1007\/s10552-012-0039-2"},{"key":"2026070712444777100_ref21","doi-asserted-by":"crossref","unstructured":"Freeman LE, Rusiecki JA, Hoppin JA, et al: Atrazine and cancer incidence among pesticide applicators in the agricultural health study (1994-2007). Environ Health Perspect 2011;119:1253-1259.10.1289\/ehp.110356121622085","DOI":"10.1289\/ehp.1103561"},{"key":"2026070712444777100_ref22","doi-asserted-by":"crossref","unstructured":"Hurley PM, Hill RN, Whiting RJ: Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect 1998;106:437-445.10.1289\/ehp.981064379681970","DOI":"10.1289\/ehp.98106437"},{"key":"2026070712444777100_ref23","unstructured":"Leon ME, Beane Freeman LE, Douwes J, et al: AGRICOH: a consortium of agricultural cohorts. Int J Environ Res Public Health 2011;8:1341-1357.10.3390\/ijerph805134121655123"},{"key":"2026070712444777100_ref24","doi-asserted-by":"crossref","unstructured":"Ward MH: Too much of a good thing? Nitrate from nitrogen fertilizers and cancer. Rev Environ Health 2009;24:357-363.10.1515\/REVEH.2009.24.4.35720384045","DOI":"10.1515\/REVEH.2009.24.4.357"},{"key":"2026070712444777100_ref25","doi-asserted-by":"crossref","unstructured":"Ward MH, Kilfoy BA, Weyer PJ, et al.: Nitrate intake and the risk of thyroid cancer and thyroid disease. Epidemiology 2010;21:389-395.10.1097\/EDE.0b013e3181d6201d20335813","DOI":"10.1097\/EDE.0b013e3181d6201d"}],"container-title":["European Thyroid Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/3\/3\/189\/28932\/etj362928.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/3\/3\/189\/28932\/etj362928.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:54:56Z","timestamp":1783443296000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article\/3\/3\/189\/3948\/Environmental-Lifestyle-and-Anthropometric-Risk"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,28]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000362928","relation":{},"ISSN":["2235-0802","2235-0640"],"issn-type":[{"value":"2235-0802","type":"electronic"},{"value":"2235-0640","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8,28]]}}}