{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T02:44:53Z","timestamp":1746326693416,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T00:00:00Z","timestamp":1400284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T00:00:00Z","timestamp":1400284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Locally advanced breast cancer (LABC) deteriorates the quality of life (QOL) of the affected patients. Combination chemotherapy or extended chemotherapy is considered to help to shrink local lesions. &lt;b&gt;&lt;i&gt;Case 1:&lt;\/i&gt;&lt;\/b&gt; A 71-year-old female with a history of tympanitis and cystitis with methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;\/i&gt; (MRSA) visited our hospital. There was a tumor of 7 cm in diameter in her right breast with skin ulceration. Paclitaxel + bevacizumab therapy was started, and after five cycles of therapy, a mastectomy with axillary dissection was performed. Chemotherapy with anthracycline was avoided for fear of activating the MRSA. After the operation, the patient's wound opened. However, it naturally epithelialized. &lt;b&gt;&lt;i&gt;Case 2:&lt;\/i&gt;&lt;\/b&gt; A 41-year-old female visited our hospital due to a tumor of 8 cm in diameter in her right breast with skin ulceration. Four cycles of paclitaxel + bevacizumab therapy were started, and her tumor almost disappeared during the first cycle. Then, doxorubicin + cyclophosphamide therapy was performed for four cycles, and a mastectomy with axillary dissection was performed. Her postoperative course was good. &lt;b&gt;&lt;i&gt;Discussion:&lt;\/i&gt;&lt;\/b&gt; Chemotherapy with bevacizumab or extended chemotherapy is generally not considered to contribute to a survival improvement. However, such therapy contributes in increasing the response to chemotherapy, and should be considered for patients with LABC to shrink the local lesions and improve the QOL.<\/jats:p>","DOI":"10.1159\/000363098","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T06:40:52Z","timestamp":1400481652000},"page":"323-329","source":"Crossref","is-referenced-by-count":1,"title":["Two Cases of Mastectomy after Paclitaxel + Bevacizumab Therapy for Locally Advanced Breast Cancer"],"prefix":"10.1159","volume":"7","author":[{"given":"Chika","family":"Shinoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryutaro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000357416"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.4639"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.1275"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.6405"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072113"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70335-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111097"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111065"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31828940c3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds658"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.52"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e32833b7598"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/363098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/363098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:45:30Z","timestamp":1745430330000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000363098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,17]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000363098","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2014,5,17]]}}}