{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:46Z","timestamp":1745469106731,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose of the Study:&lt;\/i&gt;&lt;\/b&gt; To study the expression of osteopontin (OPN) in alopecia areata (AA) lesions in a trial to clarify its possible role in the pathogenesis of such a disease. &lt;b&gt;&lt;i&gt;Procedures:&lt;\/i&gt;&lt;\/b&gt; Tissue level of OPN was measured in 28 AA patients as well as 25 age- and sex-matched healthy controls using both real-time polymerase chain reaction (PCR) and immunohistochemistry. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The tissue level of OPN by real-time PCR (4.5-12.8, 8.93 \u00b1 1.9) and immunohistochemical expression of positive OPN mean area percent (7.1-21.2%, 12 \u00b1 5.5%) were significantly higher in patients compared to controls (1-4.6, 2.11 \u00b1 0.93; 3.9-12.02%, 6.8 \u00b1 2.8%, respectively; p &lt; 0.0000). The Severity of Alopecia Tool score showed no significant correlation with the OPN mRNA expression (r = 0.11, p = 0.55). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; High OPN mRNA expression is associated with AA. OPN might play an important role in the pathogenesis of AA. \u00a9 2014 S. Karger AG, Basel<\/jats:p>","DOI":"10.1159\/000363147","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T07:31:28Z","timestamp":1413271888000},"page":"84-90","source":"Crossref","is-referenced-by-count":2,"title":["Gene Expression of Osteopontin in Alopecia Areata? 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