{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:15:47Z","timestamp":1761059747358,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background: &lt;\/i&gt;&lt;\/b&gt;Drugs used in preterm labor (PTL) have side effects. Research into new tocolytic agents is recommended. The plant &lt;i&gt;Bryophyllum pinnatum&lt;\/i&gt; (Lam.) Oken (&lt;i&gt;Kalanchoe pinnata&lt;\/i&gt; (Lam.) Pers) is used in Anthroposophic Medicine for PTL, insomnia, and emotional disturbances. The aim of this study was to evaluate the effects of &lt;i&gt;B. pinnatum&lt;\/i&gt; mother tincture (MT) on Wistar rats and their fetuses throughout pregnancy. &lt;b&gt;&lt;i&gt;Method: &lt;\/i&gt;&lt;\/b&gt;Sixty animals were divided into 6 equal groups: controls C1 and C2 received 1 and 25 \u00d7 the maximum daily dose of a 30% ethanol \/ water solution, serving as vehicle of &lt;i&gt;B. pinnatum&lt;\/i&gt; MT; B1 and B2 received 1 and 25 \u00d7 the maximum daily dose of &lt;i&gt;B. pinnatum&lt;\/i&gt; MT; and B3 and B4 received 50 and 100 \u00d7 &lt;i&gt;B. pinnatum&lt;\/i&gt; concentrate. The following parameters were assessed: weight gain; maternal and fetal mortality; implantations and resorptions; number and weight of fetuses and placentas; major external fetal malformations. &lt;b&gt;&lt;i&gt;Results: &lt;\/i&gt;&lt;\/b&gt;Rat weight gain (excluding fetal and placental weight) was higher in group B4 and lower in group B2. There were no maternal or fetal deaths and no group differences in implantations and resorptions or number and weight of fetuses and placentas. No macroscopic fetal abnormalities were observed at the 4 dosage levels investigated. &lt;b&gt;&lt;i&gt;Conclusion: &lt;\/i&gt;&lt;\/b&gt;Daily administration of &lt;i&gt;B. pinnatum&lt;\/i&gt; MT at high doses to pregnant Wistar rats interfered with maternal weight gain and did not interfere with fetal compartment.<\/jats:p>","DOI":"10.1159\/000363709","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T13:15:58Z","timestamp":1402924558000},"page":"184-189","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Chronic &lt;b&gt;&lt;i&gt;Bryophyllum pinnatum&lt;\/i&gt;&lt;\/b&gt; Administration on Wistar Rat Pregnancy"],"prefix":"10.1159","volume":"21","author":[{"given":"Jorge Kioshi","family":"Hosomi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ghelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa Pascale","family":"Quintino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Uchiyama","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Fernandes","family":"Moron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,6,16]]},"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/363709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/363709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:51:07Z","timestamp":1745430667000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000363709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000363709","archive":["Portico"],"relation":{},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"type":"print","value":"2504-2092"},{"type":"electronic","value":"2504-2106"}],"subject":[],"published":{"date-parts":[[2014]]}}}