{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:07:56Z","timestamp":1758395276838,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The progression of the cervical squamous intraepithelial lesion (SIL) is associated with many cofactors, and nutritional aspects are gradually assuming an important role in understanding the physiopathogenesis. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To assess the serum levels of retinol in women from a poor region of Brazil with a histological diagnosis of cervical high-grade SIL (HSIL). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A cross-sectional study was conducted in 62 women aged 14-48 years who had a cervical biopsy and were treated at the Federal University of Ceara in Fortaleza, Brazil. Serum retinol levels were measured in peripheral blood by a spectrophotometry technique. Values were categorized as subnormal (&lt;20 \u00b5g\/dl) or normal (\u226520 \u00b5g\/dl). Multivariate logistic regression was used to determine the association between serum levels of retinol and HSIL for a confidence interval of 95%. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twenty-six out of 62 women (42%) had a negative histopathological result for SIL and 36 (58%) were diagnosed with SIL (20 low SIL and 16 high SIL). The level of retinol was more frequently low in women with HSIL, but there was no statistical significance [p = 0.409, OR: 2.26 (0.33-15.59)]. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; There was no association between high SIL and low levels of retinol in peripheral blood.<\/jats:p>","DOI":"10.1159\/000363741","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T06:35:01Z","timestamp":1408689301000},"page":"235-238","source":"Crossref","is-referenced-by-count":3,"title":["The Risk of High-Grade Squamous Intraepithelial Lesions in Women with Low Serum Levels of Vitamin A"],"prefix":"10.1159","volume":"78","author":[{"given":"Jos\u00e9","family":"Eleut\u00e9rio Jr.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo C\u00e9sar","family":"Giraldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Katherine","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Mirian Nunes","family":"Eleut\u00e9rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita de C\u00e1ssia Carvalho","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane Isabelle Magno","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg171"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1086\/425907"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04956-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003477"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000320742"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2006000900029"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086\/315816"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1994.tb01382.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003473"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.1.61"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89101995000400007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02581-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601089727"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003296.pub2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199405000-00004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.4.4.273"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24793"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802691552"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC382_1"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/363741","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/363741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/363741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:51:26Z","timestamp":1745430686000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000363741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,11,1]]},"published-print":{"date-parts":[[2014,11,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000363741","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2014]]}}}