{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:03:08Z","timestamp":1778806988272,"version":"3.51.4"},"reference-count":52,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To correlate prenatal indicators of pulmonary hypoplasia with neonatal lung function and pulmonary hypertension (PHT) in isolated congenital diaphragmatic hernia (iCDH). &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Prospective single-center study on 40 fetuses with iCDH either expectantly managed (n = 13) or undergoing tracheal occlusion (n = 27). Prenatal predictors included observed\/expected lung-head ratio (O\/E LHR), observed\/expected total fetal lung volume, fetal pulmonary reactivity to maternal O&lt;sub&gt;2&lt;\/sub&gt; administration (&amp;#x0394;pulsatility index, &amp;#x0394;PI) and liver-to-thorax ratio (LiTR) as measured in the second and third trimesters. Postnatal outcome measures included survival until discharge, best oxygenation index (OI) and alveolar-arterial oxygen gradient [D(A-a)O&lt;sub&gt;2&lt;\/sub&gt;] in the first 24 h of life and the occurrence of PHT in the first 28 days of life. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Median gestational age (GA) at evaluations was 27.2 and 34.3 weeks. GA at delivery was 36.0 weeks, and overall survival was 55%. In the second trimester, measurement of lung size, LiTR and pulmonary reactivity were significantly related to survival and the best OI and D(A-a)O&lt;sub&gt;2&lt;\/sub&gt;.The occurrence of PHT was better predicted by &amp;#x0394;PI and LiTR. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; O\/E LHR, LiTR and vascular reactivity correlate with ventilatory parameters in the first 24 h of life. Occurrence of PHT at \u226528 days was best predicted by LiTR and &amp;#x0394;PI, but not by lung size.<\/jats:p>","DOI":"10.1159\/000364805","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T14:27:25Z","timestamp":1418048845000},"page":"24-32","source":"Crossref","is-referenced-by-count":27,"title":["Prediction of Neonatal Respiratory Function and Pulmonary Hypertension in Fetuses with Isolated Congenital Diaphragmatic Hernia in the Fetal Endoscopic Tracleal Occlusion Era: A Single-Center Study"],"prefix":"10.1159","volume":"37","author":[{"given":"Elisa","family":"Done","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Debeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Gucciardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Van Mieghem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lewi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Devlieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-9673","authenticated-orcid":false,"given":"Luc","family":"De Catte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Lewi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-5105","authenticated-orcid":false,"given":"Karel","family":"Allegaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.8725"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3841"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.532"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.06.030"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.20032"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2845"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/jpsu.2003.50194"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.009"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.022"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.069"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.147827"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000320605"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90338-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4052"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2688"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903551400"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000295262"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6141"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5168"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2413051228"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6139"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2839"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3890"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000320204"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6146"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2709-6"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.04.004"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31823d3aea"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00182-9"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1711"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.08.010"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.10.008"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322006000300003"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10142"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2108"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2756"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.08.001"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000141518.19721.D7"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12445"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6450"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.03.002"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7753"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1159\/000320622"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.127130"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7753"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2005.03.005"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2004.04.001"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.6.838"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7747"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11212"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/364805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/364805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:51:59Z","timestamp":1745430719000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000364805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,8]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015,1,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000364805","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,8]]}}}