{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:26:25Z","timestamp":1767918385513,"version":"3.49.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<jats:p>Aims: This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis. Methods: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography\/time-of-flight mass spectrometry. Results: A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid. Conclusions: Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.<\/jats:p>","DOI":"10.1159\/000364816","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T06:30:08Z","timestamp":1405060208000},"page":"252-262","source":"Crossref","is-referenced-by-count":43,"title":["Serum Metabolomic Biomarkers of Dementia"],"prefix":"10.1159","volume":"4","author":[{"given":"Malahat","family":"Mousavi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Antti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Adolfsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelie","family":"Nordin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Bergdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e5re","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars-G\u00f6ran","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Nyberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.12.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2013.01.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt96"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00530-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182477eed"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000435558.98447.17"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2008.10.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000427396.91304.3d"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.55"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1021\/ac3028307"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201300019"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1021\/ac301243k"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/13825580490511026"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12000"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1021\/ac051211v"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1021\/ac050601e"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/metabo2040796"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.01.029"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1021\/ac901143w"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.1.96"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh451"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.100529"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2011.02.002"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-12-68"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn316"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1469"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159\/000210040"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000346606"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.21.1.136"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7047-3"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3466"}],"container-title":["Dementia and Geriatric Cognitive Disorders Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/364816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/364816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:52:04Z","timestamp":1745430724000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000364816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,11]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,8,1]]},"published-print":{"date-parts":[[2014,5,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000364816","archive":["Portico"],"relation":{},"ISSN":["1664-5464"],"issn-type":[{"value":"1664-5464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,11]]}}}