{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:20Z","timestamp":1745469140096,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML) subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype.<\/jats:p>","DOI":"10.1159\/000365002","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T06:42:01Z","timestamp":1403678521000},"page":"407-409","source":"Crossref","is-referenced-by-count":1,"title":["Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report"],"prefix":"10.1159","volume":"7","author":[{"given":"Christopher","family":"Trosclair","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maressa","family":"Pollen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Capraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Cotelingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney E.","family":"Shackelford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90112-C"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402720"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(02)00075-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2007.01.012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3581"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404406"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2007.12.011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1999.01312.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000836"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:53:53Z","timestamp":1745430833000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,25]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000365002","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2014,6,25]]}}}