{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:44:09Z","timestamp":1762004649660,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Minipuberty describes transient activation of the hypothalamic-pituitary-gonadal axis occurring during the first few months of life. Hormone levels during minipuberty were described in only a few Prader-Willi syndrome (PWS) infant boys and have not been reported in PWS infant girls. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To measure gonadotropins and gonadal hormones in PWS male and female infants and assess gender-specific patterns of hormone secretion. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Hormone levels in 14 (9 male, 5 female) PWS infants ages 1-3 months were compared with reference ranges for normal infants and in 44 prepubertal PWS children (27 female, 17 male). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Compared to prepubertal boys, hormone levels (median and range) for PWS infant boys were increased: LH 2.8 mIU\/ml (1.2-6.2), FSH 4.4 mIU\/ml (1.0-19.5), testosterone 4.0 nmol\/l (3.0-7.0), inhibin B 219 pg\/ml (141-325), and AMH 79 ng\/ml (45-157). Hormone levels in infant girls were not significantly different from levels in prepubertal girls. LH, inhibin B, and AMH were higher in male infants than in female infants. LH\/FSH ratios were 0.56 (0.24-1.77) in boys versus 0.09 (0.04-0.17) in girls (p = 0.003). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Hormone levels in PWS infant boys are in the expected minipuberty range. By contrast, reproductive hormones in most PWS infant girls did not differ from levels in prepubertal girls.<\/jats:p>","DOI":"10.1159\/000365047","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T07:10:41Z","timestamp":1408950641000},"page":"230-237","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of Minipuberty in Infants with Prader-Willi Syndrome"],"prefix":"10.1159","volume":"82","author":[{"given":"Harry J.","family":"Hirsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia","family":"Eldar-Geva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matityahu","family":"Erlichman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varda","family":"Gross-Tsur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000058094"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2465"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031038"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1982.tb09552.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.12.4905"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/er.22.6.787"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2820"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0902"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000232489"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2760"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0901"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04161.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1954"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1595"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.08.077"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2171"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031624"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2103"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2325"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.2.4603"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000277140"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1502"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021468"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.81.2.8636269"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1079"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2010.03.002"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.1.8265"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0121"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:54:35Z","timestamp":1745430875000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,10,1]]},"published-print":{"date-parts":[[2014,10,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000365047","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2014]]}}}