{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:36:09Z","timestamp":1791218169147,"version":"4.1.0"},"reference-count":33,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":4189,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objectives: Pregnancy loss in women suffering from hyperthyroidism has been described in case reports, but the risk of pregnancy loss caused by maternal hyperthyroidism in a population is unknown. We aimed to evaluate the association between maternal hyperthyroidism and pregnancy loss in a population-based cohort study. Study Design: All pregnancies in Denmark from 1997 to 2008 leading to hospital visits (n = 1,062,862) were identified in nationwide registers together with information on maternal hyperthyroidism for up to 2 years after the pregnancy [hospital diagnosis\/prescription of antithyroid drug (ATD)]. The Cox proportional hazards model was used to estimate adjusted hazard ratio (aHR) with 95% confidence interval (CI) for spontaneous abortion (gestational age &amp;lt;22 weeks) and stillbirth (\u226522 weeks), reference: no maternal thyroid dysfunction. Results: When maternal hyperthyroidism was diagnosed before\/during the pregnancy (n = 5,229), spontaneous abortion occurred more often both in women treated before the pregnancy alone [aHR 1.28 (95% CI 1.18-1.40)] and in women treated with ATD in early pregnancy [1.18 (1.07-1.31)]. When maternal hyperthyroidism was diagnosed and treated for the first time in the 2-year period after the pregnancy (n = 2,361), there was a high risk that the pregnancy under study had terminated with a stillbirth [2.12 (1.30-3.47)]. Conclusions: Both early (spontaneous abortion) and late (stillbirth) pregnancy loss were more common in women suffering from hyperthyroidism. Inadequately treated hyperthyroidism in early pregnancy may have been involved in spontaneous abortion, and undetected high maternal thyroid hormone levels present in late pregnancy may have attributed to an increased risk of stillbirth.<\/jats:p>","DOI":"10.1159\/000365101","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T02:34:58Z","timestamp":1411612498000},"page":"164-172","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":75,"title":["Spontaneous Abortion, Stillbirth and Hyperthyroidism: A Danish Population-Based Study"],"prefix":"10.1530","volume":"3","author":[{"given":"Stine Linding","family":"Andersen","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark"},{"name":"2Department of Clinical Medicine, Aalborg University, Aalborg, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Olsen","sequence":"additional","affiliation":[{"name":"3Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Sen","family":"Wu","sequence":"additional","affiliation":[{"name":"3Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Laurberg","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark"},{"name":"2Department of Clinical Medicine, Aalborg University, Aalborg, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2014,8,29]]},"reference":[{"key":"2026070712445328200_ref1","unstructured":"Simpson JL, Jauniaux ER: Pregnancy loss; in Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ER, Driscoll DA (eds): Obstetrics: Normal and Problem Pregnancies, ed 6. 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