{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:45Z","timestamp":1745469165497,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2015]]},"abstract":"The human organic cation transporter 1 (hOCT1) is the major active influx protein responsible for the transport of imatinib mesylate (IM) into cells. Previous studies have used <sup>14<\/sup>C-labeled IM to demonstrate a link between chronic myeloid leukemia (CML) molecular response and hOCT1 activity. However, this method is not convenient in routine clinical practice. Hence, we detected hOCT1 protein expression levels (C<sub>hoct1<\/sub>) of peripheral blood in CML patients and evaluated the relationship between C<sub>hoct1<\/sub> and IM response. A total of 83 patients who were diagnosed with Philadelphia chromosome (Ph)-positive CML with IM therapy and 31 heathy donors were collected. C<sub>hoct1<\/sub> were detected by indirect immunofluorescent flow cytometry. The study showed that C<sub>hoct1<\/sub> expression was higher in healthy donors than in CML patients (n = 31, 9.11 \u00b1 6.04; n = 35, 5.60 \u00b1 3.74; p = 0.005). Both C<sub>hoct1<\/sub> and plasma IM trough concentration (C<sub>min<\/sub>, n = 83) were significantly higher in patients with major molecular response (MMR) than those without (p = 0.011; p = 0.001, respectively), and patients with C<sub>hoct1<\/sub> \u22654.745 and C<sub>min<\/sub> \u22651,385 ng\/ml were more likely to achieve MMR. hOCT1 expression levels measured using flow cytometry is a convenient and clinically available technique. The hOCT1 expression level can be an important predictor in CML patients treated with IM. \u00a9 2014 S. 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