{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:03:44Z","timestamp":1791475424292,"version":"4.3.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Introduction:<\/i><\/b> Neural Wiskott-Aldrich syndrome protein (N-WASP) expression is associated with tumor cell invasion and migration. However, its expression status in clear cell renal cell carcinoma (CCRCC) remains unclear. We examined the level of N-WASP in CCRCC and its association with clinicopathological features characteristic. <b><i>Materials and Methods:<\/i><\/b> 73 CCRCC patients who underwent radical nephrectomy or partial nephrectomy were enrolled. Immunohistochemical staining for N-WASP was performed on tissue microarrays constructed from tumor and para-tumor tissue obtained from these patients. The difference in N-WASP expression between tumor tissue and adjacent normal renal tissue was examined. Correlations between N-WASP expression in the tumor and clinicopathological parameters were analyzed and the relationship between N-WASP expression and overall survival also assessed. Uni- and multivariate survival analyses were performed. <b><i>Results:<\/i><\/b> N-WASP expression was significantly reduced in tumor tissues and was significantly related to the histological grade of CCRCC. A higher level of N-WASP expression in the tumor was associated with relatively poor survival in CCRCC patients. The level of N-WASP expression, age at time of surgery, and histological grade were all responsible for clinical outcome in CCRCC patients. N-WASP was an independent predictor for overall survival. <b><i>Conclusions:<\/i><\/b> N-WASP was downregulated in CCRCC and could serve as a prognostic biomarker for predicting clinical outcome of CCRCC.<\/jats:p>","DOI":"10.1159\/000365595","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T07:25:31Z","timestamp":1407396331000},"page":"79-85","source":"Crossref","is-referenced-by-count":7,"title":["Expression of Neural Wiskott-Aldrich Syndrome Protein in Clear Cell Renal Cell Carcinoma and Its Correlation with Clinicopathological Features"],"prefix":"10.1159","volume":"95","author":[{"given":"Guang-hua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-3861","authenticated-orcid":false,"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-gang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2012.161"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3322\/CA.2007.0010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90528-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01586"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.5.1680-1695.2005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200407076"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1242"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.068163"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.000596"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00224-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000145260.89322.2d"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800251"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvg146"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.092726"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-007-9120-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2009.01035.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.067"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.08.146"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:00:22Z","timestamp":1745431222000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,8,1]]},"published-print":{"date-parts":[[2015,8,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000365595","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,7]]}}}