{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:50:33Z","timestamp":1788403833177,"version":"build-2803163510"},"reference-count":17,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> The relationship between serum hormone levels and adolescent acne is not fully clarified. <b><i>Objective:<\/i><\/b> To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17\u03b1-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China. <b><i>Methods:<\/i><\/b> A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0. <b><i>Results:<\/i><\/b> Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females. <b><i>Conclusion:<\/i><\/b> Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne.<\/jats:p>","DOI":"10.1159\/000365656","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T07:43:54Z","timestamp":1416383034000},"page":"359-362","source":"Crossref","is-referenced-by-count":5,"title":["Higher 17\u03b1-Hydroxyprogesterone Levels Aggravated the Severity of Male Adolescent Acne in Northeast China"],"prefix":"10.1159","volume":"229","author":[{"given":"Bin","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Chen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Duo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chundi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7362.475"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000017859"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2165\/1153875-S0-000000000-00000"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2011.617803"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6682.1217"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03590.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-1-7-570"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1981.tb02752.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb04553.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000347196"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2011.06.984"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2009.12.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.07171.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304283081701"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02036.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04613.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:01:18Z","timestamp":1745431278000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,12,1]]},"published-print":{"date-parts":[[2014,12,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000365656","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}