{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T18:05:34Z","timestamp":1770919534473,"version":"3.50.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Lung volume reduction surgery can improve lung function and working capacity in severe heterogeneous emphysema. Endobronchial lung volume reduction (ELVR) performed by one-way valves inserted via a flexible bronchoscope can result in a moderate but significant improvement in lung function and exercise tolerance, eliminating the surgical risks. <b><i>Objectives:<\/i><\/b> Most studies of this method have excluded patients with \u03b1<sub>1<\/sub>-antitrypsin (AAT) deficiency, but small series of cases with positive short-term outcome have been reported. The sustainability of results has been questioned and we here present our experience in AAT-deficient patients treated with ELVR followed up for up to 4 years. <b><i>Methods:<\/i><\/b> From August 2008 to January 2012, 15 patients were treated with ELVR. Inclusion criteria were homozygotic AAT deficiency, age <80 years, residual volume of 140% or more, forced expiratory volume in 1 s (FEV<sub>1<\/sub>) 15-45% of predicted, severe heterogeneous emphysema, symptoms severely restricting daily life, informed consent and absence of other serious diseases. <b><i>Results:<\/i><\/b> One patient coughed up valves after 2 months, 1 developed pneumothorax and had valve displacement and subsequent removal, and 1 improved from an FEV<sub>1<\/sub> of 0.62 to 0.84 liters, but after 4 months developed repeated and severe pneumonia and the valves had to be removed. Thus, 12 patients remained and were followed up for at least 1 year. In these patients, FEV<sub>1<\/sub> increased (mean: 54%), the quality of life was much improved, and 2 patients could be taken off oxygen therapy. During the 4-year follow-up, patients demonstrated no significant deterioration in lung function. <b><i>Conclusion:<\/i><\/b> In carefully selected AAT deficiency patients with severe emphysema, ELVR can be safely performed with encouraging long-lasting results.<\/jats:p>","DOI":"10.1159\/000365662","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T07:00:57Z","timestamp":1410418857000},"page":"320-328","source":"Crossref","is-referenced-by-count":33,"title":["One- to Four-Year Follow-Up of Endobronchial Lung Volume Reduction in Alpha-1-Antitrypsin Deficiency Patients: A Case Series"],"prefix":"10.1159","volume":"88","author":[{"given":"Gunnar","family":"Hillerdal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Mindus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10010104"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1428CI"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70007-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-44"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.07.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70147-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030287"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3489"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.05.069"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000322649"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000336239"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900928"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00100110"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00161611"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000341171"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000339411"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2012.00280.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-651OC"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00056008"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2412005"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00015312"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.06.006"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00071311"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-75"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(96)00234-2"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.12.071"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:01:22Z","timestamp":1745431282000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,10,1]]},"published-print":{"date-parts":[[2014,10,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000365662","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}