{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:48:28Z","timestamp":1770706108252,"version":"3.49.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Hypertrophic scar is a fibro-proliferative disease. Our previous studies demonstrate that compound <i>Astragalus<\/i> and <i>Salvia miltiorrhiza<\/i> extract (CASE) inhibits proliferation and invasion in keloid fibroblasts. <b><i>Objective:<\/i><\/b> To investigate the effects of CASE on hypertrophic scar. <b><i>Methods:<\/i><\/b> Rabbits were divided into the control, model and three dosage groups of CASE (0.94, 1.88, 3.76%). An animal model of hypertrophic scar was established and treated with CASE ointment or ointment base. The histopathological detection by hematoxylin &#38; eosin and Masson's trichrome staining and protein expression of scars by Western blot were performed. <b><i>Results:<\/i><\/b> The hydroxyproline content was decreased under CASE treatment. Transforming growth factor beta 1 (TGF-\u03b2<sub>1<\/sub>) protein expression increased in the model group while it decreased under CASE treatment. The elevated expression of Smad4 protein was decreased under CASE treatment. Additionally, CASE promoted Smad7 protein expression. <b><i>Conclusion:<\/i><\/b> CASE could inhibit formation of hypertrophic scar by modulating TGF-\u03b2\/Smad signal and may be useful for the treatment of hyperplastic scars.<\/jats:p>","DOI":"10.1159\/000365784","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T06:37:43Z","timestamp":1409035063000},"page":"363-368","source":"Crossref","is-referenced-by-count":17,"title":["Compound <b><i>Astragalus<\/i><\/b> and <b><i>Salvia miltiorrhiza<\/i><\/b> Extract Suppresses Rabbits' Hypertrophic Scar by Modulating the TGF-\u03b2\/Smad Signal"],"prefix":"10.1159","volume":"229","author":[{"given":"Chao","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiemei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Boye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.101"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31829acf0a"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.01.016"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12265"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-013-0195-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(97)80541-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.04.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09511.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10674.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00225.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.03.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2012.4.389"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.026534"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/837581"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000429705.02588.f5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.03.032"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00598.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031350"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S35252"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2013.10.004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031157"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.08.013"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0093"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0363"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:01:56Z","timestamp":1745431316000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,12,1]]},"published-print":{"date-parts":[[2014,12,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000365784","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}