{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T19:08:06Z","timestamp":1770404886726,"version":"3.49.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The introduction of molecular diagnoses has provided evidence of the existence of several different allergenic profiles in grass-sensitised individuals, reflecting the large number of allergens involved. This methodology has become a potent tool for a correct diagnosis and for the selection of the most appropriate immunotherapy. Based on these concepts, the objectives of this study were to determine the sensitisation profile of a grass-allergic population, and to treat them with specific immunotherapy. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients suffering from rhinitis and\/or asthma associated with grass pollen were recruited. The active group was treated with depigmented-polymerised allergenic extract of mixed grass pollen. sIgE and sIgG4 to &lt;i&gt;Phleum pratense&lt;\/i&gt;, and to its individual components (Phl p 1, 2, 4, 5b, 6, 7, 11 and 12) were determined at the beginning and end of the study. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The inclusion criteria were fulfilled by 139 individuals (36 in the control group and 103 in the active group). Phl p 1 (96.4%) and Phl p 4 (91.2%) were the most recognised allergens, and 15.3% of individuals had positive IgE to cross-reactive carbohydrate determinants. Levels of antigen-specific IgG4 increased significantly after treatment, and the IgE\/IgG4 ratio decreased significantly in all allergens after receiving allergen-specific immunotherapy. Non-significant differences were observed in the control group. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; A high percentage of sensitisation to Phl p 4 was observed. Immunological efficacy was studied by measuring sIgG4 levels and the IgE\/IgG4 ratio before and after treatment. Sensitisation profiles should be taken into consideration to prepare the most appropriate immunotherapy containing all the relevant and needed allergens.<\/jats:p>","DOI":"10.1159\/000365866","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T06:59:30Z","timestamp":1411973970000},"page":"9-17","source":"Crossref","is-referenced-by-count":11,"title":["Allergenic Profile to &lt;i&gt;Phleum pratense&lt;\/i&gt; and Immunological Changes Induced after Grass Allergen-Specific Immunotherapy"],"prefix":"10.1159","volume":"165","author":[{"given":"Juan M.","family":"Beitia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Angeles","family":"L\u00f3pez-Matas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-0571","authenticated-orcid":false,"given":"Aranzazu","family":"Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Mateo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remedios","family":"C\u00e1rdenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4050-2577","authenticated-orcid":false,"given":"Jer\u00f3nimo","family":"Carn\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01393.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000024443"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000069013"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1997.1460953.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000236135"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.049"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03585.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000301580"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)78276-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03470.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00258.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.03.021"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2002.157"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02399.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.045"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12303"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.06.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32833fd5d2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000142039"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000084227"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328348a7cd"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000338995"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000232567"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/284615"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90318-V"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000353113"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90062-8"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:02:24Z","timestamp":1745431344000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,11,1]]},"published-print":{"date-parts":[[2014,11,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000365866","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}