{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:21:49Z","timestamp":1772706109577,"version":"3.50.1"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Our aim was to examine the value of indirect signs of open spina bifida in the mid-sagittal view of the posterior brain at the 11-13 weeks' ultrasound examination and to summarize the current evidence for the first-trimester diagnosis of spina bifida. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was a prospective study in routine obstetric population.&lt;b&gt; &lt;\/b&gt;The presence of four almost parallel lines (four-line view) in the posterior brain was recorded. Biparietal diameter (BPD), intracranial translucency (IT) and cisterna magna (CM) were measured. The ratio of IT to CM (R ratio) was calculated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 2,491 pregnancies were examined prospectively. Updated reference ranges for IT and CM were constructed. There were 3 cases with open spina bifida, and the four-line view was abnormal in 2 of them. The abnormal fetuses had smaller BPD as well as pronounced reduction in the CM and increase in the R ratio. &lt;b&gt;&lt;i&gt;Discussion:&lt;\/i&gt;&lt;\/b&gt; Examination of the posterior brain was feasible in all fetuses in the setting of the routine 11-13 weeks' ultrasound examination. Indirect signs of spina bifida are visible in the mid-sagittal view of the posterior brain, and the assessment of these structures can be a reliable tool in the early identification of this abnormality.<\/jats:p>","DOI":"10.1159\/000365920","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T07:55:31Z","timestamp":1424246131000},"page":"294-300","source":"Crossref","is-referenced-by-count":21,"title":["Towards Detecting Open Spina Bifida in the First Trimester: The Examination of the Posterior Brain"],"prefix":"10.1159","volume":"37","author":[{"given":"Dimitra","family":"Kappou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Papastefanou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Pilalis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Kavalakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Kassanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athena P.","family":"Souka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1775"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10060403.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.664199"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91610-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0792-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00660.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00149.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970130910"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10111"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8957"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2632"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3973"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12302"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3976"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11010030.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7718"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10088"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12420"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11175"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.014"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000335677"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9067"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11079"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2869"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:33:34Z","timestamp":1745429614000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,5,1]]},"published-print":{"date-parts":[[2015,5,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000365920","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}