{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:36:09Z","timestamp":1790040969561,"version":"4.0.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<b><i>Purpose:<\/i><\/b> To evaluate the efficacy of 2 dexamethasone intravitreal implants and 1 ranibizumab intravitreal injection after a bilateral postoperative complication of cataract surgery as pseudophakic cystoid macular edema. <b><i>Patients and Methods:<\/i><\/b> A 70-year-old male patient with systemic hypertension developed a progressive cystoid macular edema (CME) in both eyes starting between 10 and 20 days after cataract surgery. Two intravitreal dexamethasone implants and 1 ranibizumab injection were administered; first in the right eye (RE) and then in the left eye (LE). The patient was checked for 1 whole week and then once a month for 5 months after the injections. <b><i>Results:<\/i><\/b> One month after the first dexamethasone implant in his RE, the spectral domain optical coherence tomography (SD-OCT) showed a progressive reduction of the foveal thickness until a complete resolution of the CME occurred, which was associated with an improvement of visual acuity. After 3 months, the SD-OCT showed a relapse of the CME, which was then treated with 1 injection of ranibizumab. One month after this injection, there was a complete resolution of the CME. A new CME in his RE was diagnosed 2 months after the last ranibizumab injection; it was treated with a new dexamethasone implant. A complete resolution of the CME was obtained; a normal foveal profile was still present 5 months after the last injection, and the best-corrected visual acuity was 20\/20. His LE developed a CME 40 days after surgery. One intravitreal injection of ranibizumab was first administered in his LE, with a complete resolution of the CME at SD-OCT 2 weeks later. As observed in his RE, 40 days after the ranibizumab injection, there was a relapse of the CME that was treated with 1 intravitreal injection of dexamethasone implant. Five months later, the patient showed a worsening of the CME, but it was completely resolved with a second dexamethasone injection. After 3 months, the foveal thickness was back to normal with a BCVA of 20\/20. <b><i>Conclusion:<\/i><\/b> Treatment with dexamethasone implants (Ozurdex\u00ae) and ranibizumab injections (Lucentis\u00ae) induced a progressive reduction of our patient's CME after cataract surgery (Irvine-Gass syndrome) until a complete normal foveal thickness was restored and his visual function was improved despite the order of injections.<\/jats:p>","DOI":"10.1159\/000365945","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:46:58Z","timestamp":1492552018000},"page":"243-248","source":"Crossref","is-referenced-by-count":8,"title":["Intravitreal Injection of Dexamethasone Implant and Ranibizumab in Cystoid Macular Edema in the Course of Irvine-Gass Syndrome"],"prefix":"10.1159","volume":"5","author":[{"given":"Vito","family":"Fenicia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Balestrieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Perdicchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Maurizi Enrici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Delle Fave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santi Maria","family":"Recupero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32834cd5f8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200302000-00007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2014.050.03.2103755"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000342160"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-011-0019-z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S36811"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e3181c551da"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01938-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.04.006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.033"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/365945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:33:52Z","timestamp":1745429632000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000365945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,4]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000365945","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,4]]}}}