{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:07Z","timestamp":1745469067955,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background: &lt;\/i&gt;&lt;\/b&gt;In order to further improve the methodology and quality of data collection in homeopathic drug provings (HDP), there is a need for a minimum standardised HDP protocol. The objective of the present study was to test the feasibility of this type of protocol. &lt;b&gt;&lt;i&gt;Materials and Methods: &lt;\/i&gt;&lt;\/b&gt;The study protocol embraced a multi-centre, randomised, double-blind, placebo-controlled trial with 2 parallel groups. It was approved by an ethics review committee. During the pre-approval phase, discordances between the regulatory and homeopathic requirements for the protocol were checked and solutions found. The study medication was &lt;i&gt;Potentilla anserina&lt;\/i&gt;. 6 participants received verum and 4 placebo. The resulting symptom list will be published elsewhere. The procedure was accepted by all participants. &lt;b&gt;&lt;i&gt;Results: &lt;\/i&gt;&lt;\/b&gt;Three important issues were addressed: the requirement to keep all participants blinded; the adverse events reporting to regulatory authorities; and the necessity of a placebo control group. Other issues that need further investigations were identified, e.g. sample size, observation period and dosage regimen. &lt;b&gt;&lt;i&gt;Conclusions: &lt;\/i&gt;&lt;\/b&gt;A minimum protocol of a HDP is feasible. All important design elements of HDP could be solved in discussions with the respective regulatory authorities, and participating homeopaths accepted the procedure.<\/jats:p>","DOI":"10.1159\/000366042","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T07:01:38Z","timestamp":1410418898000},"page":"232-238","source":"Crossref","is-referenced-by-count":3,"title":["A Minimum Protocol for Randomised Homeopathic Drug Proving as Basis for Further Research"],"prefix":"10.1159","volume":"21","author":[{"given":"Jean Pierre","family":"Jansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingegerd","family":"Hildingsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miek C.","family":"Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2006.11.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000082120"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000209386"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2005.02.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-11-80"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp050105"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(97)00203-5"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/366042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/366042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:34:45Z","timestamp":1745429685000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000366042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000366042","archive":["Portico"],"relation":{},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"type":"print","value":"2504-2092"},{"type":"electronic","value":"2504-2106"}],"subject":[],"published":{"date-parts":[[2014]]}}}