{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:34:47Z","timestamp":1787312087356,"version":"build-2736575974"},"reference-count":30,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2014]]},"abstract":"The purpose of this research was to describe the pharmacokinetic parameters of \u03b2-hydroxyphosphocarnitine (\u03b2-HPC; CAS No. 1220955-20-3) after a single oral dose in rats and rabbits as well as to assess the impact of 14 weeks of \u03b2-HPC (100 mg\/kg) treatment on the serum metabolites and liver enzymes, body weight, and hepatic steatosis of lean and obese Zucker <i>fa\/fa<\/i> rats. In the case of the rat and rabbit study, the \u03b2-HPC area under the curve, biological half-life, and clearance were 2,174.4 versus 3,128 \u03bcg<b>\u2219<\/b>h\/ml, 23.7 versus 8.87 h, and 13.9 versus 151.1 ml\/h in the rats versus the rabbits, respectively. The values for the time of maximal concentration were 0.58 versus 1.53 h, for the maximal concentration, they were 62.4 versus 221.4 \u03bcg\/ml, and for the absorption rate constant 0.02 versus 2.40 h<sup>-1<\/sup>, respectively. In the case of the Zucker <i>fa\/fa<\/i> rat study, \u03b2-HPC administered orally once a day reduced insulin, triglyceride, and cholesterol levels in the liver and serum; it also reduced weight gain and decreased liver steatosis in obese rats after 14 weeks. \u03b2-HPC could therefore potentially be used in the treatment of metabolic syndrome.<\/jats:p>","DOI":"10.1159\/000366205","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T02:56:05Z","timestamp":1410749765000},"page":"90-98","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetic and Pharmacological Effects of \u03b2-Hydroxyphosphocarnitine in Animal 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