{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:39:00Z","timestamp":1792600740898,"version":"4.5.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2015]]},"abstract":"In 2013, Nangalia et al. and Klampfl et al. found a recurrent and abundant mutation in the calreticulin gene <i>(CALR)<\/i>, mutually exclusive with <i>JAK2<\/i> and <i>MPL<\/i> alterations. At present, the data concerning the new mutation, i.e. its prevalence, allele burden and clinical significance, are scarce. We report the incidence and molecular characteristics of <i>CALR<\/i> mutations in a group of 184 Polish patients with myeloproliferative neoplasms (MPNs). Clinical data analysis revealed significant differences between <i>JAK2<\/i> V617F-mutated and <i>CALR<\/i>-mutated groups. In essential thrombocythemia patients, hemoglobin levels and leukocyte counts were significantly higher in <i>JAK2<\/i>-positive than in <i>CALR<\/i>-positive patients (p = 0.023 and p = 0.017, respectively), but the <i>CALR<\/i>-positive patients had significantly higher platelet counts (p = 0.022). Patients harboring <i>CALR<\/i> mutations were also younger at the time of diagnosis (p = 0.039). In primary myelofibrosis patients, the degree of anemia was less severe in those who were <i>CALR<\/i> exon 9 mutation-positive than in those who were <i>JAK2<\/i> V617F-positive (p = 0.048). \u00a9 2014 S. Karger AG, Basel<\/jats:p>","DOI":"10.1159\/000366263","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:52:04Z","timestamp":1492552324000},"page":"193-198","source":"Crossref","is-referenced-by-count":13,"title":["Frequency and Molecular Characteristics of Calreticulin Gene <b><i>(CALR)<\/i><\/b> Mutations in Patients with <b><i>JAK2<\/i><\/b>-Negative Myeloproliferative Neoplasms"],"prefix":"10.1159","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-2723","authenticated-orcid":false,"given":"Marzena","family":"Wojtaszewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Iwo\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03546"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71142-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312542"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311347"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.219"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08083.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008893"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/PDM.0b013e3181ecd261"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.49"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205269200"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-9639(02)00441-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001375"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.03.015"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412759"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-530865"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.35"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-538983"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.83"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-539098"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.382"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23743"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.100"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.148"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/366263","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/366263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/366263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:36:47Z","timestamp":1745429807000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000366263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,16]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,1]]},"published-print":{"date-parts":[[2015,2,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000366263","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,16]]}}}