{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:28:46Z","timestamp":1788492526505,"version":"build-2803163510"},"reference-count":85,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Objective: The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) was introduced in thyroid cytology in 2007 and is now generally accepted. BSRTC categories include a morphologic description and risk of malignancy as well as follow-up suggestions in each group. However, the category entitled \u2018atypia of undetermined significance or follicular lesion of undetermined significance' (AUS\/FLUS) is problematic. This category is heterogeneous and has been overused so far. Study Design: Twenty-six studies were included in a meta-analysis. In addition to AUS\/FLUS percentage, we analysed repeated AUS\/FLUS percentage, cytological and histological correlations, and risk of malignancy and neoplasm for AUS\/FLUS. Furthermore, stratification, inter- and intra-observer variability, and the possibility of a switch to another category and its clinical consequences were reviewed. Results: Out of a total of 81,833 cases, AUS\/FLUS accounted for 10.9%, with a 34% risk of malignancy. Persistent AUS\/FLUS was found in 21.6% in repeated cytology. Cytohistological correlation was analysed from 16 studies (4,964 cases), revealing 10.4% as AUS\/FLUS and a 21.5% risk of malignancy. Conclusions: An AUS\/FLUS category seems to be currently reasonable with clearly defined cytomorphological criteria which do not correspond unequivocally with those of the other categories. An AUS\/FLUS category is justified and possible means of its improvement with immunohistochemistry, molecular analysis and imaging are discussed.<\/jats:p>","DOI":"10.1159\/000366498","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T06:42:39Z","timestamp":1411368159000},"page":"319-329","source":"Crossref","is-referenced-by-count":65,"title":["Thyroid Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance: An Indispensable Bethesda 2010 Diagnostic Category or Waste 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