{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:44:58Z","timestamp":1788993898341,"version":"build-2803163510"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Immunoadsorption (IAS) and therapeutic plasma exchange (TPE) are considered safe although fibrinogen is removed. To date no comparison of fibrinogen reduction and associated risk of bleeding in apheresis exists. <b><i>Methods:<\/i><\/b> Retrospective analysis of TPE, three IAS adsorbers, and combined TPE\/IAS regarding fibrinogen reduction and bleeding incidence in 67 patients (1,032 treatments). <b><i>Results:<\/i><\/b> TPE and TPE\/IAS reduced fibrinogen by 64 \u00b1 11% and 58 \u00b1 9%, leading to concentrations <100 mg\/dl in 20 and 17% of treatments, respectively. IAS decreased fibrinogen less than TPE (26 \u00b1 6%, p < 0.0001), resulting in fibrinogen concentrations <100 mg\/dl in 1% of treatments. The processed volume correlated with reduction in TPE (r = 0.64, p < 0.01), but not in IAS. Bleeding occurred in 1.3% (IAS), 2.3% (TPE) and 3.1% (TPE\/IAS) of treatments. <b><i>Conclusion:<\/i><\/b> Hypofibrinogenemia occurs in 20% of patients after TPE and TPE\/IAS, but rarely after IAS. IAS removes fibrinogen independently of volume processed. Overall, bleeding is rare in apheresis.<\/jats:p>","DOI":"10.1159\/000367682","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T07:42:40Z","timestamp":1417678960000},"page":"160-166","source":"Crossref","is-referenced-by-count":61,"title":["Fibrinogen Reduction and Bleeding Complications in Plasma Exchange, Immunoadsorption and a Combination of the Two"],"prefix":"10.1159","volume":"38","author":[{"given":"Simon","family":"Z\u00f6llner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonore","family":"Pablik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred","family":"Druml","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Derfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-2186","authenticated-orcid":false,"given":"Peter","family":"Biesenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00720.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2005.00306.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.00627.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb01172.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/jca.1026"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04424.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00184.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.029660"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000148732.26761.FA"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/jca.10023"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000291619.17160.b8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(09)71824-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04972.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20217"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20143"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2005.00319.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00998.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/cc10129"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03247.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0958"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/cc10488"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10558-010-9092-1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(09)71820-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00944.x"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:41:49Z","timestamp":1745430109000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000367682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,12,1]]},"published-print":{"date-parts":[[2014,12,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000367682","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}