{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:26:25Z","timestamp":1779927985932,"version":"3.53.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> The effect of isotretinoin (ISO) on adipokines and insulin resistance has been investigated in a few studies, and the results are conflicting. <b><i>Objective:<\/i><\/b> The aim of this study was to investigate the effect of ISO treatment on insulin resistance and adipokines. <b><i>Methods:<\/i><\/b> Thirty-three patients with acne vulgaris and a control group of 30 healthy volunteers were included in our study. Screening for the biochemical parameters was performed just before the initiation and after 3 months of ISO treatment. <b><i>Results:<\/i><\/b> In the acne group, basal leptin levels were significantly lower (p = 0.003) and basal adiponectin levels significantly higher (p = 0.008) compared with the control group. After ISO treatment, leptin levels (p = 0.0005) decreased and adiponectin levels (p = 0.003) increased significantly. However, measurements of fasting blood glucose, insulin, C peptide, retinol-binding protein 4 (RBP4), homeostasis model assessment insulin resistance and BMI did not differ after ISO treatment. <b><i>Conclusion:<\/i><\/b> ISO may affect leptin and adiponectin levels. It does not, however, affect insulin resistance and RBP4 levels.<\/jats:p>","DOI":"10.1159\/000367687","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T15:49:22Z","timestamp":1420472962000},"page":"70-74","source":"Crossref","is-referenced-by-count":17,"title":["The Effect of Isotretinoin on Retinol-Binding Protein 4, Leptin, Adiponectin and Insulin Resistance in Acne Vulgaris Patients"],"prefix":"10.1159","volume":"230","author":[{"given":"Ayse Serap","family":"Karadag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derun Taner","family":"Ertugrul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zennure","family":"Takci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap Gunes","family":"Bilgili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Namuslu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naim","family":"Ata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Sekeroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,1,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.1.13900"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700743"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2003.07.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2174\/157016112803520864"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03915.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0498"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2007.04.007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00054-X"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10949.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0232"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S340"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054862"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25798"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0458"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:41:51Z","timestamp":1745430111000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000367687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,2,1]]},"published-print":{"date-parts":[[2015,2,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000367687","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}