{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:29:25Z","timestamp":1778074165039,"version":"3.51.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Neurally adjusted ventilatory assist (NAVA) is a novel mode of ventilation that has been demonstrated to improve infant-ventilator interaction, compared to the conventional modes in retrospective and short-term studies. <b><i>Objectives:<\/i><\/b> To prospectively evaluate the physiologic effects of NAVA in comparison with pressure-regulated volume control (PRVC) in two nonrandomized 12-hour periods. <b><i>Methods:<\/i><\/b> We studied 14 consecutive intubated preterm neonates receiving mechanical ventilation for acute respiratory failure. Peak airway pressure (Paw<sub>peak<\/sub>), diaphragm electrical activity (EAdi), tidal volume (V<sub>T<\/sub>), mechanical (RR<sub>mec<\/sub>) and neural (RR<sub>neu<\/sub>) respiratory rates, neural apneas, and the capillary arterialized blood gases were measured. The RR<sub>mec<\/sub>-to-RR<sub>neu<\/sub> ratio (MNR) and the asynchrony index were also calculated. The amount of fentanyl administered was recorded. <b><i>Results:<\/i><\/b> Paw<sub>peak<\/sub> and V<sub>T<\/sub> were greater in PRVC (p < 0.01). Blood gases and RR<sub>mec<\/sub> were not different between modes, while RR<sub>neu<\/sub> and the EAdi swings were greater in NAVA (p = 0.02 and p < 0.001, respectively). MNR and the asynchrony index were remarkably lower in NAVA than in PRVC (p = 0.03 and p < 0.001, respectively). 1,841 neural apneas were observed during PRVC, with none in NAVA. Less fentanyl was administered during NAVA, as opposed to PRVC (p < 0.01). <b><i>Conclusions:<\/i><\/b> In acutely ill preterm neonates, NAVA can be safely and efficiently applied for 12 consecutive hours. Compared to PRVC, NAVA is well tolerated with fewer sedatives.<\/jats:p>","DOI":"10.1159\/000367886","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T07:47:34Z","timestamp":1415346454000},"page":"60-67","source":"Crossref","is-referenced-by-count":57,"title":["Neurally Adjusted Ventilatory Assist in Preterm Neonates with Acute Respiratory Failure"],"prefix":"10.1159","volume":"107","author":[{"given":"Federico","family":"Longhini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"De 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