{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:23:38Z","timestamp":1771550618890,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; We investigated the prognosis of patients with small-cell neuroendocrine carcinoma of the uterine cervix (SCNEC) in relation to treatment modalities. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We retrospectively reviewed the medical records and pathological reports of 102 patients who were histologically diagnosed with SCNEC at 5 different institutes. Time to progression (TTP) and overall survival (OS) were analyzed for each treatment modality. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of the patients with early-stage [International Federation of Obstetrics and Gynecology (FIGO) stage IB2 or below] SCNEC, 57.8 and 79.3% underwent radical hysterectomy followed by adjuvant therapy. In advanced-stage SCNEC, concurrent chemoradiation therapy was given to 51.4% of the patients. The overall recurrence rate was 51.6%. In early- and advanced-stage SCNEC, the TTP was not different (22.3 vs. 13.3 months, p = 0.104), but the OS was different (40.7 vs. 21.4 months, p = 0.029). Parametrial involvement and lymph vascular space invasion were found to be associated with an unfavorable prognosis. Interestingly, survival was the most unfavorable in patients with early-stage SCNEC who had never received chemotherapy. FIGO stage and use of chemotherapy were identified as independent prognostic factors in SCNEC patients. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; SCNEC requires systemic chemotherapy as part of the initial treatment, along with surgery or radiation, even in patients with early-stage disease.<\/jats:p>","DOI":"10.1159\/000367920","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T08:27:04Z","timestamp":1418286424000},"page":"172-178","source":"Crossref","is-referenced-by-count":22,"title":["A Multicenter Study of the Importance of Systemic Chemotherapy for Patients with Small-Cell Neuroendocrine Carcinoma of the Uterine Cervix"],"prefix":"10.1159","volume":"79","author":[{"given":"Shin-Wha","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Taek","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk Soo","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu-Rae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Hyun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.15219.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.10.028"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00409-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000084259"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1489::AID-CNCR10>3.3.CO;2-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(92)90077-V"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.12.027"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198809000-00005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000108600"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181ce427b"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00433887"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22235"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75941-3_10"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1035"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/00016349509021185"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<712::AID-CNCR12>3.0.CO;2-V"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm465"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.11.010"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1385"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.04.019"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000356685"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000353899"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367920","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:44:38Z","timestamp":1745430278000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000367920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,11]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,4,1]]},"published-print":{"date-parts":[[2015,4,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000367920","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,11]]}}}