{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:31:32Z","timestamp":1773275492261,"version":"3.50.1"},"reference-count":38,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> Controversy exists regarding the diagnosis and treatment of mild congenital hypothyroidism (MCH). We studied the value of <sup>123<\/sup>I imaging in patients with MCH. <b><i>Methods:<\/i><\/b> Retrospective chart review of infants and children <4 years of age who underwent <sup>123<\/sup>I imaging: group 1 = MCH [thyroid-stimulating hormone (TSH) <25 \u00b5IU\/ml, normal free T<sub>4<\/sub>\/T<sub>3<\/sub>], group 2 = severe congenital hypothyroidism (TSH \u226525 \u00b5IU\/ml), and group 3 = MCH in infancy imaged after treatment withdrawal at age 3 years. Data collected included 4- and 24-hour <sup>123<\/sup>I uptake, TSH, free T<sub>4<\/sub>\/total T<sub>3<\/sub> at imaging, age at imaging, and levothyroxine (<smlcap>L<\/smlcap>-T<sub>4<\/sub>) dose at 1 year of. <b><i>Results:<\/i><\/b> Thirty-six patients underwent <sup>123<\/sup>I imaging. In group 1 (n = 20, median TSH: 8.49 \u00b5IU\/ml), 85% had abnormal imaging consistent with dyshormonogenesis. Two patients were referred after 1 year of age. The median age at imaging for the remaining 18 patients was 54 days. Median <smlcap>L<\/smlcap>-T<sub>4<\/sub> dose at 1 year of age for these 18 patients was 2.8 \u03bcg\/kg, which is consistent with dyshormonogenesis. Ninety-one percent of group 2 (n = 11, median TSH: 428.03 \u00b5IU\/ml) had abnormal imaging. The median age at imaging was 13 days. Four patients in group 3 had abnormal <sup>123<\/sup>I imaging and restarted treatment. <b><i>Conclusion:<\/i><\/b><sup>123<\/sup>I imaging is a valuable tool for evaluation, diagnosis, and treatment of MCH.<\/jats:p>","DOI":"10.1159\/000367992","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T07:57:23Z","timestamp":1418716643000},"page":"94-101","source":"Crossref","is-referenced-by-count":4,"title":["The Role of <sup>123<\/sup>I Imaging in the Evaluation of Infants with Mild Congenital Hypothyroidism"],"prefix":"10.1159","volume":"83","author":[{"given":"Evan","family":"Graber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly O.","family":"Regelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Annunziato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Machac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rapaport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1175"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.03.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1850"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3273"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03568.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.103351"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.07.024"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1903"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.120268"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.77.4.8408462"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1711"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.1656"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0915"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000358198"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.096776"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100290"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000251"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.084327"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.12.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0803"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-3-523"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3174"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.1.186"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000100373"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2007.20.4.501"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2006.19.1.31"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80005-5"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)90049-0"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0057"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.7.3209"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2612"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.160"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1159\/000151597"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02831.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.107111"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214341"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.17.2051"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0405"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:45:12Z","timestamp":1745430312000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000367992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,16]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,3,1]]},"published-print":{"date-parts":[[2015,3,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000367992","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,16]]}}}