{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:53:00Z","timestamp":1769457180637,"version":"3.49.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Poly-T repeat lengths of rs10524523 in <i>TOMM40<\/i> together with <i>APOE<\/i> polymorphism have been reported to affect the risk of late-onset Alzheimer's disease (LOAD) and the age of onset (AOO). <b><i>Objective:<\/i><\/b> To explore whether the AOO and cerebrospinal fluid biomarkers A\u03b242, total tau and phosphorylated tau are associated with different repeat lengths. <b><i>Methods:<\/i><\/b> We conducted both the fragment and sequencing analysis of rs10524523 in 336 LOAD patients with a known <i>APOE<\/i> genotype. <b><i>Results:<\/i><\/b> AOO and A\u03b242 levels associated significantly with certain poly-T repeat lengths of rs10524523 in LOAD patients encompassing <i>APOE<\/i> 34\/44 genotype. <b><i>Conclusion:<\/i><\/b> We conclude that the poly-T repeat associations of rs10524523 in <i>TOMM40<\/i> reflect the <i>APOE<\/i> \u03b54-dependent association in LOAD.<\/jats:p>","DOI":"10.1159\/000367994","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T07:38:58Z","timestamp":1418801938000},"page":"204-208","source":"Crossref","is-referenced-by-count":7,"title":["The Effect of <b><i>TOMM40<\/i><\/b> Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients"],"prefix":"10.1159","volume":"14","author":[{"given":"Seppo","family":"Helisalmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esa-Heikki","family":"Meril\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viljami","family":"V\u00e4is\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne 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Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/367994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:45:13Z","timestamp":1745430313000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000367994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015,1,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000367994","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}