{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:44Z","timestamp":1745469104844,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To evaluate trends of nasal bone length (NBL), prenasal thickness (PT), nuchal fold (NF), prenasal thickness to nasal bone length (PT-NBL) ratio, and prefrontal space ratio (PFSR), measured serially in second- and third-trimester Down syndrome (DS) fetuses. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Prenatal databases were searched for cases of continuing DS pregnancies with serial measurements, taken at least two weeks apart. Trends were plotted on previously reported normal ranges. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Serial measurements were available in 25 Down syndrome fetuses. Median gestational age (GA) was 25 weeks; average number of visits per case was 2.44, with a median interval of 39 days between investigations. In DS fetuses, NBL and PT showed fairly stable trends with gestation. PFSR, but especially NF, had a more unpredictable trend. The PT-NBL ratio was the most stable marker, remaining unchanged in 95% of cases. NBL, PT, and NF showed more deviance from the normal range with advancing gestation, but MoM values remained stable. All but two fetuses had ultrasound markers or structural anomalies, especially heart defects. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The PT-NBL ratio is the most constant DS marker throughout gestation, following a predictable trend.<\/jats:p>","DOI":"10.1159\/000368047","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T07:41:42Z","timestamp":1422603702000},"page":"48-54","source":"Crossref","is-referenced-by-count":3,"title":["Trends in Serial Measurements of Ultrasound Markers in Second and Third Trimester Down Syndrome Fetuses"],"prefix":"10.1159","volume":"38","author":[{"given":"F.I.","family":"Vos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.P.","family":"De Jong-Pleij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Tromp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Bilardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.078"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/uog.31"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.119082"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1207"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5404"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5307"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80279-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4091"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2323"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13391"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9047"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000350271"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13291"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10058"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7471"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711263172203"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-2315(05)82740-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12261"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.126975"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s004290050123"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2009.107"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/1933719107314062"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8819"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2006.02.003"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00582.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9024"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05060381.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4521"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:45:29Z","timestamp":1745430329000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,8,1]]},"published-print":{"date-parts":[[2015,8,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000368047","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2015]]}}}