{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:10:07Z","timestamp":1778692207300,"version":"3.51.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Naftopidil, an \u03b1&lt;sub&gt;1&lt;\/sub&gt;-adrenoceptor blocker, induced apoptosis of human malignant pleural mesothelioma NCI-H2052 cells. Naftopidil upregulated the expression of tumor necrosis factor-\u03b1 (TNF-\u03b1) mRNA in these cells. Naftopidil, alternatively, increased FasL secretion from NCI-H2052 cells, without affecting the expression of FasL mRNA and protein, and activated caspase-3 and -8 in NCI-H2052 cells. Naftopidil drastically suppressed tumor growth in mice inoculated with these cells. The results of the present study indicate that naftopidil induces apoptosis of NCI-H2052 cells by upregulating the expression of TNF-\u03b1 and stimulating the secretion of FasL, a ligand for the death receptor Fas, both to activate caspase-8 and the effector caspase-3, leading to the suppression of NCI-H2052 cell proliferation in vivo. This raises the possibility that naftopidil could be developed as an effective drug for the treatment of malignant pleural mesothelioma.<\/jats:p>","DOI":"10.1159\/000368050","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T07:32:15Z","timestamp":1413271935000},"page":"163-169","source":"Crossref","is-referenced-by-count":8,"title":["Naftopidil Is Useful for the Treatment of Malignant Pleural Mesothelioma"],"prefix":"10.1159","volume":"94","author":[{"given":"Koji","family":"Mikami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Nagaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Nishizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67025-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050152"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/oem.17.4.260"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1728-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2012.05.111"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.5869"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-269"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.79.447"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23095"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0189"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000342797"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000339048"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1305"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00521-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.6.1675"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:45:30Z","timestamp":1745430330000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":16,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2014,11,1]]},"published-print":{"date-parts":[[2014,11,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000368050","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}