{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:22:38Z","timestamp":1775121758609,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Few studies have evaluated the efficacy of carbon dioxide (CO<sub>2<\/sub>) laser ablation for treating neurofibromatosis type 1 (NF1). <b><i>Objective:<\/i><\/b> To evaluate laser treatment safety and patient satisfaction at the French National Referral Centre for Neurofibromatosis. <b><i>Methods:<\/i><\/b> Retrospective survey with a specific questionnaire. The principal outcome measures included pain evaluation and assessments of treatment safety. <b><i>Results:<\/i><\/b> We included 106 patients, 70% of whom had more than 50 neurofibromas. Laser treatment was performed mostly for aesthetic reasons, or due to pain, recurrent local trauma or familial influence, under a local anaesthetic, during outpatient visits. The mean pain score was 4.0 \u00b1 2.7 during the administration of local anaesthesia, 2.4 \u00b1 2.1 during laser treatment and <2 48 h after treatment in 56% of cases. The mean satisfaction score for the treatment was 4.6 \u00b1 3.4 and was not associated with disease phenotype. <b><i>Conclusions:<\/i><\/b> CO<sub>2<\/sub> laser treatment for NF could be considered more frequently and might help to decrease the social impact of the disease.<\/jats:p>","DOI":"10.1159\/000368078","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T07:25:15Z","timestamp":1422948315000},"page":"263-268","source":"Crossref","is-referenced-by-count":31,"title":["Treatment of Neurofibromas with a Carbon Dioxide Laser: A Retrospective Cross-Sectional Study of 106 Patients"],"prefix":"10.1159","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-378X","authenticated-orcid":false,"given":"C\u00e9cile","family":"M\u00e9ni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Sbidian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Christophe","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9verine","family":"Lafaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Buffard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Goldzal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Wolkenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Valeyrie-Allanore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.11.704"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2004.06.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.051"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.1.2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06558.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000168830.79997.13"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.169"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000187594"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.11.1421"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31422"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08949.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04214.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199106000-00016"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900030402"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900160103"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:45:47Z","timestamp":1745430347000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,1]]},"published-print":{"date-parts":[[2015,3,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000368078","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}