{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:48Z","timestamp":1745469108455,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>A 54-year-old female presented with a 2-week history of increasing shortness of breath and fever. She had a history of a poorly differentiated sigmoid adenocarcinoma for which she underwent an anterior resection 6 months prior to admission, followed by 12 cycles of adjuvant FOLFOX chemotherapy. The patient was treated for a severe community-acquired pneumonia; however, she remained hypoxic. A chest CT revealed extensive right-sided fibrotic changes, tractional dilatation of the airways and ground glass density, which had developed since a staging CT scan performed 2 months previously. Although her symptoms improved with steroid therapy, repeat imaging revealed that right hydropneumothorax had developed, and this required the insertion of a chest drain. Following its successful removal, the patient continues to improve clinically and radiographically. The rapid onset and nature of these changes is consistent with a drug-induced fibrotic lung disease secondary to FOLFOX chemotherapy. The phenomenon is underreported and yet, it is relatively common: it occurs in approximately 10% of patients who are treated with antineoplastic agents, although information specifically relating to FOLFOX-induced pulmonary toxicity is limited. It is associated with significant morbidity and mortality, but is often hard to differentiate from other lung conditions, making the diagnosis a challenge. Pulmonary toxicity is an important complication associated with antineoplastic agents. It should be considered in any patient on a chemotherapeutic regimen who presents with dyspnoea and hypoxia in order to try to reduce the associated morbidity and mortality.<\/jats:p>","DOI":"10.1159\/000368185","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T06:29:08Z","timestamp":1411540148000},"page":"662-668","source":"Crossref","is-referenced-by-count":7,"title":["Pulmonary Fibrosis Secondary to FOLFOX Chemotherapy: A Case Report"],"prefix":"10.1159","volume":"7","author":[{"given":"Wai Cheong","family":"Soon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gibeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Frances","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj057"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11670-011-0232-y"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.09.046"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.045"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000331898"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.09.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2174\/092986707779313345"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200208000-00014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-008-0863-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq061"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3393\/jksc.2011.27.5.266"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq195"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.0928"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:46:40Z","timestamp":1745430400000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,24]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000368185","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2014,9,24]]}}}