{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T01:11:57Z","timestamp":1780794717439,"version":"3.54.1"},"reference-count":32,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Acute kidney injury (AKI) is common in hospitalised patients and is associated with adverse long-term consequences. There is an urgent need to understand these sequelae in general hospitalised patients utilising a prospective cohort-based approach. We aimed to test the feasibility of study methodology prior to commencing a large-scale study and investigate the effects of AKI on chronic kidney disease (CKD) progression and proteinuria. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Pilot study testing novel methodology for remote patient recruitment within a prospective case-control design. 300 cases (hospitalised patients with AKI) and controls (hospitalised patients without AKI) were matched 1:1 for age and baseline estimated glomerular filtration rate (eGFR). 70% of cases had AKI stage 1, 16% AKI stage 2 and 14% AKI stage 3. Renal function and proteinuria were measured 3 and 12 months after hospital admission. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The study met pre-defined recruitment, withdrawal and matching criteria. Renal function was worse in the AKI group at 3 (eGFR 61 \u00b1 20 vs. 74 \u00b1 23 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;, p &lt; 0.001) and 12 months (eGFR 64 \u00b1 23 vs. 75 \u00b1 25 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;, p &lt; 0.001). More cases than controls had CKD progression at 3 months (14 vs. 0.7%, p &lt; 0.001). This difference persisted to 12 months, but there was no significant change between 3 and 12 months. Proteinuria and albuminuria were more prevalent in the AKI group and associated with CKD progression. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; We describe a method of remote patient recruitment which could be employed more widely for prospective observational studies. Even mild AKI is associated with long-term renal dysfunction. Further investigation using this methodology is now underway.<\/jats:p>","DOI":"10.1159\/000368243","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T07:34:32Z","timestamp":1418369672000},"page":"192-200","source":"Crossref","is-referenced-by-count":20,"title":["The Effects of Acute Kidney Injury on Long-Term Renal Function and Proteinuria in a General Hospitalised Population"],"prefix":"10.1159","volume":"128","author":[{"given":"Kerry L.","family":"Horne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Packington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Monaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Selby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000319972"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.05.011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000224227.70642.4F"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000337487"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090740"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.379"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007080837"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-58"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.08.031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.258"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.514"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.289"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1310102"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08970911"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.479"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr708"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e328313675c"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.1361"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.14-1-22"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.13-3-233"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b866"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61271-8"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000032"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00017.2010"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011121185"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001601"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000314658"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-14-88"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12101112"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06480612"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.451"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:47:09Z","timestamp":1745430429000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,28]]},"references-count":32,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2014,12,1]]},"published-print":{"date-parts":[[2014,12,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000368243","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,28]]}}}