{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:55Z","timestamp":1792020835606,"version":"4.4.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Betahistine is a histamine-like drug that is considered beneficial in M\u00e9ni\u00e8re's disease by increasing cochlear blood flow. Acting as an agonist at the histamine H&lt;sub&gt;1&lt;\/sub&gt;-receptor and as an inverse agonist at the H&lt;sub&gt;3&lt;\/sub&gt;-receptor, these receptors as well as the adrenergic \u03b1&lt;sub&gt;2&lt;\/sub&gt;-receptor were investigated for betahistine effects on cochlear blood flow. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 54 Dunkin-Hartley guinea pigs were randomly assigned to one of nine groups treated with a selection of H&lt;sub&gt;1&lt;\/sub&gt;-, H&lt;sub&gt;3&lt;\/sub&gt;- or \u03b1&lt;sub&gt;2&lt;\/sub&gt;-selective agonists and antagonists together with betahistine. Cochlear blood flow and mean arterial pressure were recorded for 3 min before and 15 min after infusion. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Blockage of the H&lt;sub&gt;3&lt;\/sub&gt;- or \u03b1&lt;sub&gt;2&lt;\/sub&gt;-receptors caused a suppression of betahistine-mediated typical changes in cochlear blood flow or blood pressure. Activation of H&lt;sub&gt;3&lt;\/sub&gt;-receptors caused a drop in cochlear blood flow and blood pressure. H&lt;sub&gt;1&lt;\/sub&gt;-receptors showed no involvement in betahistine-mediated changes of cochlear blood flow. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Betahistine most likely affects cochlear blood flow through histaminergic H&lt;sub&gt;3&lt;\/sub&gt;-heteroreceptors.<\/jats:p>","DOI":"10.1159\/000368293","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T21:01:37Z","timestamp":1435352497000},"page":"283-293","source":"Crossref","is-referenced-by-count":29,"title":["Histaminergic H&lt;sub&gt;3&lt;\/sub&gt;-Heteroreceptors as a Potential Mediator of Betahistine-Induced Increase in Cochlear Blood Flow"],"prefix":"10.1159","volume":"20","author":[{"given":"Mattis","family":"Bertlich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Ihler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Freytag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard G.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Strupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Canis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,6,27]]},"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:47:55Z","timestamp":1745430475000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,10,1]]},"published-print":{"date-parts":[[2015,10,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000368293","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4056555","asserted-by":"subject"}]},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}