{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:53:40Z","timestamp":1790009620222,"version":"4.0.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"12","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background: &lt;\/i&gt;&lt;\/b&gt;Ipilimumab has been shown to improve overall survival in patients with metastatic melanoma; however, complete responses (CRs) are uncommon. Immune-related side effects usually involve the skin or gastrointestinal tract. Neurologic events occur less frequently but are well described. &lt;b&gt;&lt;i&gt;Case Report: &lt;\/i&gt;&lt;\/b&gt;We report the case of a 58-year-old man with metastatic melanoma who commenced ipilimumab post spinal decompression and radiation. He developed a colitis post cycle 2 and ipilimumab was discontinued. Imaging, however, documented a radiological CR. 8 weeks later, he developed paraplegia and a myelitis despite an ongoing radiological CR. Steroid use resulted in some improvement radiologically, without clinical improvement. &lt;b&gt;&lt;i&gt;Conclusion: &lt;\/i&gt;&lt;\/b&gt;We report myelitis with consequent paraplegia as a potential neurological immune-related side effect of ipilimumab. We further describe a patient with a CR after 2 cycles of ipilimumab in the setting of radiation.<\/jats:p>","DOI":"10.1159\/000368316","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T02:41:31Z","timestamp":1416796891000},"page":"757-760","source":"Crossref","is-referenced-by-count":35,"title":["Late-Onset Paraplegia after Complete Response to Two Cycles of Ipilimumab for Metastatic Melanoma"],"prefix":"10.1159","volume":"37","author":[{"given":"Grainne M.","family":"O'Kane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas G.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle C.","family":"Colleran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzuki Wan","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scheryll","family":"Alken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin C.","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05708.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104621"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203421"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1024"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70334-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1927"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.205"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.5716"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0187"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24951"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.10.023"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112824"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.12280"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr028"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e318156e47e"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.7886"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e318193a206"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-011-9787-1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.1683"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou001"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:48:16Z","timestamp":1745416096000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000368316","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}