{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:00:26Z","timestamp":1772164826777,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background\/Aims: <\/i><\/b>This study aimed to investigate the potential beneficial anti-proteinuric effect of an add-on aldosterone blockade and the impact of the aldosterone escape phenomenon. <b><i>Methods: <\/i><\/b>We retrospectively analyzed data of 304 patients with persistent proteinuria, who were administered spironolactone (25 mg\/day) after treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) for >3 months. Patients were divided according to their aldosterone levels during ACEI\/ARB treatment into an escape group (plasma aldosterone >80 pg\/mL, N=95, 31.5%) and a non-escape group (plasma aldosterone \u226480 pg\/mL, N=209, 68.5%) and according to their urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR). <b><i>Results: <\/i><\/b>After 12 months, the UACR decreased significantly in patients with 1\u2264UACR<3.5 g\/g Cr, UACR \u22653.5 g\/g Cr, and eGFR \u226560 mL\/min\/1.73 m<sup>2<\/sup>, and in the non-escape group. Severe hyperkalemia (K\u22657.0 mEq\/L) developed in 9 of 137 patients with eGFR<60 mL\/min\/1.73 m<sup>2<\/sup> (6.5%) and in none of the 167 patients with eGFR\u226560 mL\/min\/1.73 m<sup>2<\/sup>. <b><i>Conclusions: <\/i><\/b>Proteinuria decreased significantly after add-on spironolactone treatment in patients with 1\u2264UACR<3.5 g\/g Cr, UACR \u22653.5 g\/g Cr, and eGFR \u226560 mL\/min\/1.73 m<sup>2<\/sup>, and in the non-escape group. The anti-proteinuric effect of spironolactone may vary according to the degree of albuminuria, impaired eGFR, and aldosterone escape.<\/jats:p>","DOI":"10.1159\/000368470","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T05:14:17Z","timestamp":1419311657000},"page":"573-580","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Spironolactone in Combination with Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients with Proteinuria"],"prefix":"10.1159","volume":"39","author":[{"given":"Ha Yeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Hui","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Kwon","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Wan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.10.040"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(99)00046-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70536-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-003-0087-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.03.007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.158113"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000222003.28517.99"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000203772.78696.67"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000255636.11931.a2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq750"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801317"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61236-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03350708"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.505"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.9.2106"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000237742"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft281"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs429"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001854"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.008748"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00537.2009"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:50:21Z","timestamp":1745416221000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,12,1]]},"published-print":{"date-parts":[[2014,12,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000368470","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725306962.793503548","asserted-by":"object"}]},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}