{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:31:40Z","timestamp":1781850700839,"version":"3.54.5"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Cutaneous findings associated with hemophagocytic lymphohistiocytosis (HLH) remain largely undescribed in the literature, yet are substantial and correlative with disease course. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To catalog the clinical findings of cutaneous eruptions associated with HLH. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We performed a retrospective chart review of patients meeting the criteria for HLH at two hospitals over 5 years. All patients meeting the criteria for HLH as defined by the HLH-2004 protocol were included. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Cutaneous lesions were categorized based on clinical presentations and histology. Lesions independent of immunocompromised state were observed, including pyoderma gangrenosum, panniculitis, morbilliform eruptions, Stevens-Johnson syndrome, atypical targetoid lesions and bullae. Histologic findings were non-specific. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Cutaneous eruptions as a consequence of HLH are variable in presentation and identified as a diagnosis of exclusion. Findings are both primarily and secondarily induced by altered immunity. Further study is needed to allow better understanding of the immunopathogenesis involved.<\/jats:p>","DOI":"10.1159\/000368552","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T07:41:58Z","timestamp":1423726918000},"page":"234-243","source":"Crossref","is-referenced-by-count":18,"title":["Cutaneous Findings in Hemophagocytic Lymphohistiocytosis"],"prefix":"10.1159","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8506-4238","authenticated-orcid":false,"given":"Michele L.","family":"Zerah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"DeWitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12293"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2005.00564.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.9.1208"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70284-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09549.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.11.024"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834ec9c1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00167.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200307000-00021"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02742.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.025833-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181c80ab9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03368.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-12-996"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1993.tb08668.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:51:28Z","timestamp":1745430688000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,1]]},"published-print":{"date-parts":[[2015,3,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000368552","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}