{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:58:02Z","timestamp":1790708282679,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:00:00Z","timestamp":1416614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:00:00Z","timestamp":1416614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Addict Res"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Opioid maintenance treatment is the option of choice to stabilize opioid-dependent patients. Whilst efficacy of methadone and buprenorphine has been studied extensively, fewer data on slow-release oral morphine are available. &lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; This study analyzes the effects of slow-release oral morphine compared to methadone with regard to self-reported mental symptoms, drug use and satisfaction with treatment. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The study was carried out as an open-label randomized crossover trial in 14 treatment sites in Switzerland and Germany. It comprised 2 crossover periods of 11 weeks each. For measuring mental symptoms, the Symptom Checklist-27 (SCL-27) was used. Drug and alcohol use was assessed by the number of consumption days, and treatment satisfaction by a visual analogue scale. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 157 patients were included for the analyses (per-protocol sample). Statistically significantly better outcomes for morphine as compared to methadone treatment were found for overall severity of mental symptoms (SCL-27 Global Severity Index), as well as 5 of the 6 syndrome groups of the SCL-27, and for treatment satisfaction. There were no statistically significant differences with regard to drug or alcohol use between groups. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This study supports positive effects of slow-release oral morphine compared to methadone on patient-reported outcomes such as mental symptoms and treatment satisfaction with comparable effects on concomitant drug use. Slow-release oral morphine represents a meaningful alternative to methadone for treatment of opioid dependence.<\/jats:p>","DOI":"10.1159\/000368572","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T07:41:31Z","timestamp":1416814891000},"page":"97-104","source":"Crossref","is-referenced-by-count":32,"title":["Mental Symptoms and Drug Use in Maintenance Treatment with Slow-Release Oral Morphine Compared to Methadone: Results of a Randomized Crossover Study"],"prefix":"10.1159","volume":"21","author":[{"given":"Uwe","family":"Verthein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Reimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,11,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002207.pub3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03923.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003410.pub4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009879.pub2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199713030-00006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00190-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/add.12440"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2005.001128.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02334.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03463.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000090423"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000113724"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-814786"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000259089"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3182664ecd"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003267.pub2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2006.11.009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-13-104"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109\/13651501003660484"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3109\/13651501.2010.523791"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-36"}],"container-title":["European Addiction Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368572","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:51:51Z","timestamp":1745430711000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,22]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015,1,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000368572","archive":["Portico"],"relation":{},"ISSN":["1022-6877","1421-9891"],"issn-type":[{"value":"1022-6877","type":"print"},{"value":"1421-9891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,22]]}}}