{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:43:10Z","timestamp":1759228990528,"version":"3.40.5"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To compare the quality of perilymphatic enhancement in the rat inner ear after intratympanic injection of two types of gadolinium with a 9.4-tesla micro-MRI. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Gadolinium was injected into the middle ear in 6 Sprague-Dawley rats via the transtympanic route. The left ear was injected with Gd-DO3A-butrol first, and then the right ear was injected with Gd-DOTA. MR images of the inner ear were acquired 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, and 4 h after intratympanic (IT) injection using an Agilent MRI system 9.4T\/160\/AS. The normalized signal intensity was quantitatively analyzed at the scala vestibuli (SV), scala media, and scala tympani (ST) using a Marosis M-view system. Then the normalized signal intensities (SIs) were compared between the two contrast agents. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; For Gd-DO3A-butrol, the SI was as low as 1.0-1.5 throughout 1-4 h at the SV and ST of the basal turn. The maximum SI was 1.5 \u00b1 0.5 at the SV (2 h) and 1.3 \u00b1 0.5 at the ST (2 h). For Gd-DOTA, the 1-hour postinjection SI at the basal turn was 2.5 \u00b1 0.5 at the SV, 1.6 \u00b1 0.3 at the ST, and 1.2 \u00b1 0.3 at the scala media. In the apical turn, the maximum SI was reached after 2.5 h. The maximum SI in the apical turn was 1.8 \u00b1 0.4 at the SV (3.5 h), 1.8 \u00b1 0.4 at the ST (4 h), and 1.4 \u00b1 0.3 at the scala media (4 h). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; We were able to clearly visualize and separate the ST and SV using IT Gd and 9.4-tesla micro-MRI. We recommend using Gd-DO3A-butrol over Gd-DOTA and to perform the MRI 2.5 h after using IT Gd in the rat inner ear.<\/jats:p>","DOI":"10.1159\/000368666","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T13:16:59Z","timestamp":1425475019000},"page":"112-116","source":"Crossref","is-referenced-by-count":7,"title":["Diverse Patterns of Perilymphatic Space Enhancement in the Rat Inner Ear after Intratympanic Injection of Two Different Types of Gadolinium: A 9.4-Tesla Magnetic Resonance Study"],"prefix":"10.1159","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5110-5134","authenticated-orcid":false,"given":"Mina","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Sun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Jae","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeonjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ha","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung-Whan","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.07.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22089"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815c1a61"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2009.08.014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31820e7614"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.635383"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-011-0280-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3427"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31827752b4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3182539554"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-005-0046-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.10.101"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.2012-0071"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31802c300c"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.05.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.639085"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182990e81"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2010.507781"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2821"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080\/00016480902729850"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.09.015"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:53:05Z","timestamp":1745430785000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,4,1]]},"published-print":{"date-parts":[[2015,4,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000368666","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4542640","asserted-by":"subject"}]},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"type":"print","value":"1420-3030"},{"type":"electronic","value":"1421-9700"}],"subject":[],"published":{"date-parts":[[2015]]}}}