{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:56:07Z","timestamp":1788314167942,"version":"build-2803163510"},"reference-count":17,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":4105,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Papillary thyroid carcinoma is the most common thyroid cancer (85%). Follicular thyroid carcinoma is the second most common type of thyroid cancer, accounting for up to 10% of all thyroid cancers. Medullary thyroid carcinoma accounts for only 5-8% of thyroid cancers. Concurrent medullary, follicular, and papillary carcinomas of the thyroid gland are extremely rare and reported scarcely. Case Report: A 72-year-old male presented with nonspecific neck pain. The workup revealed a nodular thyroid gland with a follicular lesion on fine-needle aspiration. Total thyroidectomy was performed and pathological examination identified a 25-mm follicular carcinoma, two papillary microcarcinomas, and two medullary microcarcinomas. The genetic workup was negative and no other family members were diagnosed with any endocrinopathy. Two months after surgery, the patient was diagnosed with Cushing's syndrome that was treated with laparoscopic left adrenalectomy. On 3-year follow-up, the patient is asymptomatic with no evidence of recurrent disease. Conclusion: We present a rare case of a patient with follicular, papillary, and medullary thyroid carcinoma, and Cushing's syndrome. To date, no known genetic mutation or syndrome can account for this combination of neoplastic thyroid and adrenal pathologies, although future research may prove differently.<\/jats:p>","DOI":"10.1159\/000368750","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T02:40:58Z","timestamp":1416796858000},"page":"65-68","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":9,"title":["Concurrent Medullary, Papillary, and Follicular Thyroid Carcinomas and Simultaneous Cushing's Syndrome"],"prefix":"10.1530","volume":"4","author":[{"given":"Haggi","family":"Mazeh","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Orlev","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Mizrahi","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Gross","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert R.","family":"Freund","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2014,11,22]]},"reference":[{"key":"2026070713055788200_ref1","doi-asserted-by":"crossref","unstructured":"Siegel R, Ma J, Zou Z, Jemal A: Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29.10.3322\/caac.2120824399786","DOI":"10.3322\/caac.21208"},{"key":"2026070713055788200_ref2","doi-asserted-by":"crossref","unstructured":"American Thyroid Association Guidelines Task Force, Kloos RT, Eng C, Evans DB, Francis GL, Gagel RF, Gharib H, Moley JF, Pacini F, Ringel MD, Schlumberger M, Wells SA Jr: Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 2009;19:565-612.10.1089\/thy.2008.040319469690","DOI":"10.1089\/thy.2008.0403"},{"key":"2026070713055788200_ref3","doi-asserted-by":"crossref","unstructured":"Roy M, Chen H, Sippel RS: Current understanding and management of medullary thyroid cancer. Oncologist 2013;18:1093-1100.10.1634\/theoncologist.2013-005324037980","DOI":"10.1634\/theoncologist.2013-0053"},{"key":"2026070713055788200_ref4","doi-asserted-by":"crossref","unstructured":"Gonzalez-Campora R, Lopez-Garrido J, Martin-Lacave I, Miralles-Sanchez EJ, Villar JL: Concurrence of a symptomatic encapsulated follicular carcinoma, an occult papillary carcinoma and a medullary carcinoma in the same patient. Histopathology 1992;21:380-382.10.1111\/j.1365-2559.1992.tb00412.x1398541","DOI":"10.1111\/j.1365-2559.1992.tb00412.x"},{"key":"2026070713055788200_ref5","doi-asserted-by":"crossref","unstructured":"Cupisti K, Raffel A, Ramp U, Wolf A, Donner A, Krausch M, Eisenberger CF, Knoefel WT: Synchronous occurrence of a follicular, papillary and medullary thyroid carcinoma in a recurrent goiter. Endocr J 2005;52:281-285.10.1507\/endocrj.52.28115863962","DOI":"10.1507\/endocrj.52.281"},{"key":"2026070713055788200_ref6","unstructured":"Mazeh H, Sippel RS: Surgical management of medullary thyroid cancer. Minerva Endocrinol 2012;37:329-334.23235189"},{"key":"2026070713055788200_ref7","unstructured":"Wojciechowska K, Lewinski A: BRAF mutations in papillary thyroid carcinoma. Endocr Regul 2006;40:129-138.17201587"},{"key":"2026070713055788200_ref8","unstructured":"Taccaliti A, Boscaro M: Genetic mutations in thyroid carcinoma. Minerva Endocrinol 2009;34:11-28.19209125"},{"key":"2026070713055788200_ref9","doi-asserted-by":"crossref","unstructured":"Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K; North American Neuroendocrine Tumor Society (NANETS): The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas 2010;39:775-783.10.1097\/MPA.0b013e3181ebb4f020664475","DOI":"10.1097\/MPA.0b013e3181ebb4f0"},{"key":"2026070713055788200_ref10","doi-asserted-by":"crossref","unstructured":"Raffel A, Cupisti K, Krausch M, Wolf A, Schulte KM, Roher HD: Incidentally found medullary thyroid cancer: treatment rationale for small tumors. World J Surg 2004;28:397-401.10.1007\/s00268-003-7121-614994142","DOI":"10.1007\/s00268-003-7121-6"},{"key":"2026070713055788200_ref11","doi-asserted-by":"crossref","unstructured":"American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19:1167-1214.10.1089\/thy.2009.011019860577","DOI":"10.1089\/thy.2009.0110"},{"key":"2026070713055788200_ref12","doi-asserted-by":"crossref","unstructured":"Cheung K, Roman SA, Wang TS, Walker HD, Sosa JA: Calcitonin measurement in the evaluation of thyroid nodules in the United States: a cost-effectiveness and decision analysis. J Clin Endocrinol Metab 2008;93:2173-2180.10.1210\/jc.2007-249618364376","DOI":"10.1210\/jc.2007-2496"},{"key":"2026070713055788200_ref13","doi-asserted-by":"crossref","unstructured":"Yip DT, Hassan M, Pazaitou-Panayiotou K, Ruan DT, Gawande AA, Gaz RD, Moore FD Jr, Hodin RA, Stephen AE, Sadow PM, Daniels GH, Randolph GW, Parangi S, Lubitz CC: Preoperative basal calcitonin and tumor stage correlate with postoperative calcitonin normalization in patients undergoing initial surgical management of medullary thyroid carcinoma. Surgery 2011;150:1168-1177.10.1016\/j.surg.2011.09.04322136837","DOI":"10.1016\/j.surg.2011.09.043"},{"key":"2026070713055788200_ref14","doi-asserted-by":"crossref","unstructured":"Pillarisetty VG, Katz SC, Ghossein RA, Tuttle RM, Shaha AR: Micromedullary thyroid cancer: how micro is truly micro? Ann Surg Oncol 2009;16:2875-2881.10.1245\/s10434-009-0595-119568813","DOI":"10.1245\/s10434-009-0595-1"},{"key":"2026070713055788200_ref15","doi-asserted-by":"crossref","unstructured":"Pakdaman MN, Rochon L, Gologan O, Tamilia M, Garfield N, Hier MP, Black MJ, Payne RJ: Incidence and histopathological behavior of papillary microcarcinomas: study of 429 cases. Otolaryngol Head Neck Surg 2008;139:718-722.10.1016\/j.otohns.2008.08.01418984270","DOI":"10.1016\/j.otohns.2008.08.014"},{"key":"2026070713055788200_ref16","doi-asserted-by":"crossref","unstructured":"Barbosa SL, Rodien P, Leboulleux S, Niccoli-Sire P, Kraimps JL, Caron P, Archambeaud-Mouveroux F, Conte-Devolx B, Rohmer V; Groupe d'Etude des Tumeurs Endocrines: Ectopic adrenocorticotropic hormone-syndrome in medullary carcinoma of the thyroid: a retrospective analysis and review of the literature. Thyroid 2005;15:618-623.10.1089\/thy.2005.15.61816029131","DOI":"10.1089\/thy.2005.15.618"},{"key":"2026070713055788200_ref17","doi-asserted-by":"crossref","unstructured":"Landry CS, Waguespack SG, Perrier ND: Surgical management of nonmultiple endocrine neoplasia endocrinopathies: state-of-the-art review. Surg Clin North Am 2009;89:1069-1089.10.1016\/j.suc.2009.06.02019836485","DOI":"10.1016\/j.suc.2009.06.020"}],"container-title":["European Thyroid Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/4\/1\/65\/35554\/etj368750.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/4\/1\/65\/35554\/etj368750.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:41:05Z","timestamp":1783446065000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article\/4\/1\/65\/4845\/Concurrent-Medullary-Papillary-and-Follicular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,22]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000368750","relation":{},"ISSN":["2235-0802","2235-0640"],"issn-type":[{"value":"2235-0802","type":"electronic"},{"value":"2235-0640","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,22]]}}}