{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:22:26Z","timestamp":1782847346482,"version":"3.54.5"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,12,13]],"date-time":"2014-12-13T00:00:00Z","timestamp":1418428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2014,12,13]],"date-time":"2014-12-13T00:00:00Z","timestamp":1418428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>In this study, we examined the effect of invariant natural killer T (iNKT) cells on the function of lung dendritic cells (LDCs) in eliciting protective immunity against Chlamydia pneumoniae (Cpn) lung infection. We employed a combination of approaches including the use of iNKT cell-deficient, J\u03b118-knockout (KO) mice and LDC adoptive transfer. We found that iNKT cells significantly altered the number, phenotype and cytokine profile of LDCs following infection. Furthermore, coculture of T cells with LDCs from Cpn-infected wild-type (WT) and KO mice induced type-1 and type-2 responses, respectively. More importantly, upon adoptive transfer, LDCs from Cpn-infected WT mice (WT-LDCs) conferred protective immunity, whereas LDCs from KO mice (KO-LDCs) increased the severity of disease after challenge infection. Further cytokine analyses of the lung tissues and lung-draining lymph node cells showed that KO-LDC-recipient mice exhibited a type-2 cytokine production pattern, while WT-LDC recipients exhibited a type-1 cytokine profile. Taken together, our results provide in vivo evidence that iNKT cells play a critical role in modulating LDC function to generate protective T-cell immunity, particularly in a clinically relevant intracellular bacterial infection.<\/jats:p>","DOI":"10.1159\/000368779","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T08:41:41Z","timestamp":1418632901000},"page":"260-274","source":"Crossref","is-referenced-by-count":20,"title":["Invariant Natural Killer T Cells Promote T Cell Immunity by Modulating the Function of Lung Dendritic Cells during Chlamydia pneumoniae Infection"],"prefix":"10.1159","volume":"7","author":[{"given":"Sudhanshu","family":"Shekhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony George","family":"Joyee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0311134"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200410-1384SO"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.9.4457"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.11.2019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01609.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080314"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141711"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110983"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.19"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102555"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro931"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2009.10.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200804-517OC"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901348"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.16.3.9070619"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1838"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00452-09"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004204"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis413"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002348"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20064"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.1048"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01700.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.537"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2008.00512.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00809.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2524"}],"container-title":["Journal of Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/jin\/article-pdf\/7\/3\/260\/3905562\/000368779.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/jin\/article-pdf\/7\/3\/260\/3905562\/000368779.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:54:35Z","timestamp":1745430875000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,13]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,4,1]]},"published-print":{"date-parts":[[2015,4,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000368779","archive":["Portico"],"relation":{},"ISSN":["1662-811X","1662-8128"],"issn-type":[{"value":"1662-811X","type":"print"},{"value":"1662-8128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,13]]}}}