{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:30:02Z","timestamp":1747193402572,"version":"3.40.5"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>An 82-year-old male with a history of pars plana vitrectomy and lensectomy 6 years before presented with symptomatic macular edema (ME) from superotemporal branch retinal vein occlusion. He was sequentially treated with intravitreal agents, bevacizumab (IVB) 1.25 mg, ranibizumab (RBZ) 0.5, 1.0 and 2 mg, triamcinolone acetonide (IVTA) 1 mg, and aflibercept (IAI) 2 mg. The therapeutic benefit from IVB and RBZ was short-lived - although a decrease in ME and improvement in visual acuity were observed, a completely dry macula was not achieved even after 1 week of treatment with any dose of these agents, including 2.0 mg RBZ. IVTA achieved a dry macula for 7 weeks. IAI yielded a dry macula and improved vision with monthly injections. However, regression of the therapeutic benefit was noted at 5 weeks after the IAI injection. A stronger affinity of IAI to vascular endothelial growth factor (VEGF) compared to other anti-VEGF agents is likely responsible for the observed therapeutic effect for 1 month, making this agent preferable for the management of symptomatic ME in a vitrectomized eye.<\/jats:p>","DOI":"10.1159\/000368794","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T06:32:17Z","timestamp":1413959537000},"page":"335-342","source":"Crossref","is-referenced-by-count":3,"title":["Management of Macular Edema Secondary to Branch Retinal Vein Occlusion in an Eye with Prior Vitrectomy and Lensectomy"],"prefix":"10.1159","volume":"5","author":[{"given":"Pankaj","family":"Malhotra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-2413","authenticated-orcid":false,"given":"Kamal","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.02.022"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.233"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.02.048"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182753b12"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.134874"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10164"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2495-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318217373c"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.041"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.032"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0B013E31822C290F"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200507000-00002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01969-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318206d18c"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.06.033"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2012.727521"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:54:44Z","timestamp":1745430884000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000368794","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"type":"electronic","value":"1663-2699"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}