{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:27:47Z","timestamp":1761823667961,"version":"3.40.5"},"reference-count":38,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We investigated the relationship of body mass index at presentation and pituitary status with long-term changes in BMI over a period of 5 years. &lt;b&gt;&lt;i&gt;Study Design:&lt;\/i&gt;&lt;\/b&gt; Craniopharyngioma patients (n = 25) attending a tertiary pediatric endocrine center were divided into three groups based on their BMI at presentation [BMI \u22652 standard deviation scores (SDS), 0-1.99 SDS, and &lt;0 SDS) and then analyzed for trends of BMI over a period of up to 5 years. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Median (interquartile range) BMI SDS and hypopituitarism at presentation versus at the 5-year follow-up were as follows: BMI SDS \u22652 group (n = 10): 3.55 (0.68), 6\/10 versus 3.76 (1.13), 8\/10; BMI SDS 0-1.99 group (n = 11): 1.68 (1.05), 3\/11 versus 1.64 (2.04), 7\/11, and BMI SDS &lt;0 group (n = 4): -0.23 (0.93), 2\/4 versus 0.61, 4\/4. At the 5-year follow-up, 10\/10, 7\/11, and 1\/4 subjects when divided in groups according to BMI at presentation were obese. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our data indicate that obesity at presentation, rather than panhypopituitarism either at or after presentation, predicts obesity 5 years after diagnosis. However, obesity at presentation is not always associated with the subsequent development of panhypopituitarism. Pediatric craniopharyngioma subjects who have BMI SDS \u22652 at presentation require early and aggressive intervention to help prevent the complications of obesity.<\/jats:p>","DOI":"10.1159\/000368798","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T08:47:05Z","timestamp":1414658825000},"page":"372-379","source":"Crossref","is-referenced-by-count":12,"title":["Longitudinal Changes in Body Mass Index in Children with Craniopharyngioma"],"prefix":"10.1159","volume":"82","author":[{"given":"Muhammad Jaffar","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadija Nuzhat","family":"Humayun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-5549","authenticated-orcid":false,"given":"S. Faisal","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Guftar","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,10,30]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1186\/1824-7288-37-38"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1055\/s-0032-1330091"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1007\/s00381-005-1205-6"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1159\/000023562"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.2741\/2366"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1038\/nature05026"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1203\/pdr.0b013e3180332cd6"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1111\/j.1365-2265.2011.03993.x"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1210\/jc.2009-2003"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1055\/s-2004-832339"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1055\/s-2003-45499"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1159\/000120858"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1210\/jc.2003-031751"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1055\/s-2001-16855"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1210\/jc.2004-0667"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1111\/j.1365-2265.2010.03838.x"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1111\/j.1651-2227.2010.01867.x"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1159\/000110612"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1136\/bmj.320.7244.1240"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1086\/317533"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1515\/JPEM.2006.19.2.121"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1055\/s-2003-42722"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1111\/j.1651-2227.1988.tb10705.x"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1530\/EJE-11-0158"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1210\/jc.81.7.2734"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1038\/sj.ejcn.1600922"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.1038\/sj.ejcn.1601608"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1159\/000185531"},{"doi-asserted-by":"publisher","key":"ref29","DOI":"10.1016\/j.critrevonc.2013.07.013"},{"doi-asserted-by":"publisher","key":"ref30","DOI":"10.1210\/jc.2012-3928"},{"doi-asserted-by":"publisher","key":"ref31","DOI":"10.1093\/neuonc\/nos097"},{"doi-asserted-by":"publisher","key":"ref32","DOI":"10.1530\/eje.0.1380089"},{"doi-asserted-by":"publisher","key":"ref33","DOI":"10.1210\/jc.2003-030442"},{"doi-asserted-by":"publisher","key":"ref34","DOI":"10.1210\/jc.2002-021797"},{"doi-asserted-by":"publisher","key":"ref35","DOI":"10.1210\/jc.87.8.3993"},{"doi-asserted-by":"publisher","key":"ref36","DOI":"10.1210\/jc.2007-2672"},{"doi-asserted-by":"publisher","key":"ref37","DOI":"10.1007\/s00381-009-1078-1"},{"doi-asserted-by":"publisher","key":"ref38","DOI":"10.1007\/s00431-010-1347-8"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:54:46Z","timestamp":1745430886000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015,1,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000368798","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2014]]}}}