{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:26:42Z","timestamp":1768703202807,"version":"3.49.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Topical epinephrine application to the duodenal papilla reduces spasm of the sphincter of Oddi and prevents acute pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP). Shakuyakukanzoto (TJ-68) has an inhibitory effect on muscle contraction. Therefore, TJ-68 potentially allows the relaxation of the sphincter of Oddi, which can aid in the prevention of post-ERCP pancreatitis. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Thirty-six patients planned for ERCP were divided into TJ-68 (n = 17) and control groups (n = 19). In the TJ-68 group, the TJ-68 solution was endoscopically sprayed directly onto the duodenal papilla of patients. To assess the effects of TJ-68, serum amylase levels were measured at 1 h and 1 day after ERCP and symptoms were evaluated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The serum amylase levels at 1 h after ERCP were 273.6 \u00b1 212.0 IU\/l in the TJ-68 group and 428.7 \u00b1 281.6 IU\/l in the control group, showing a statistically significant difference (p = 0.036). The serum amylase levels at 24 h after ERCP were 230.0 \u00b1 182.7 IU\/l in the TJ-68 group and 497.4 \u00b1 514.0 IU\/l in the control group (p = 0.011). Post-ERCP pancreatitis was observed in 0 and 4 patients (21.1%) in the TJ-68 and control groups, respectively, which was not statistically significant (p = 0.11). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Direct TJ-68 solution application to the duodenal papilla significantly inhibited the elevation of serum amylase levels. However, the preventive effect regarding post-ERCP pancreatitis was not confirmed in this study.<\/jats:p>","DOI":"10.1159\/000368812","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T15:42:40Z","timestamp":1421682160000},"page":"42-45","source":"Crossref","is-referenced-by-count":8,"title":["Direct Spraying of Shakuyakukanzoto onto the Duodenal Papilla: A Novel Method for Preventing Pancreatitis following Endoscopic Retrograde Cholangiopancreatography"],"prefix":"10.1159","volume":"91","author":[{"given":"Haruka","family":"Fujinami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kajiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03594.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70112-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00380.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966723"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-198603000-00009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-14260"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199609263351302"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.12.1768"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0554-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02367779"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1443-1661.2000.00019.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2658-x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01165.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05096.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.140756"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00671-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.122616"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.08.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000106774"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)82725-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2272-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3937\/kampomed.46.293"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X03001144"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.6.153"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-008-0304-6"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368812","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/368812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:54:54Z","timestamp":1745430894000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000368812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015,1,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000368812","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}